{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:04:12Z","timestamp":1792717452393,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":3912,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background.<\/jats:italic> Cervical lymph node metastasis has a major influence on survival in oral cancer. However, the factors influencing its occurrence are uncertain. Our aim was to improve the prognostic efficiency of the histologic assessment of the primary tumor in predicting metastasis in an individual patient.<\/jats:p><jats:p><jats:italic>Methods.<\/jats:italic> The relationship between selected clinical and histologic features of the primary tumor of tongue\/floor of the mouth and the actual metastatic status was investigated in 45 patients. Invasive cell grading was supplemented by histologic measurements of tumor size and assessments of vascular and perineural invasion.<\/jats:p><jats:p><jats:italic>Results.<\/jats:italic> Ten histologic features showed significant differences in relation to metastasis. A logistic regression model with two predictor variables (total histologic malignancy score and vascular invasion) classified correctly 39 (87%) of the 45 cases.<\/jats:p><jats:p><jats:italic>Conclusions.<\/jats:italic> Histologic assessment of tumor size and malignancy grade are useful in predicting metastasis. Vascular and perineural invasion are important predictors and should be included in multifactorial malignancy grading schemes. Application of the prognostic index to the biopsy specimen would aid in treatment planning. \u00a9 1995 Jons Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/hed.2880170603","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T22:38:41Z","timestamp":1172097521000},"page":"463-472","source":"Crossref","is-referenced-by-count":217,"title":["Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue\/floor of mouth"],"prefix":"10.1002","volume":"17","author":[{"given":"Julia A.","family":"Woolgar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841867509132692"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197604)37:4<1901::AID-CNCR2820370440>3.0.CO;2-U"},{"key":"e_1_2_1_4_2","first-page":"25","article-title":"Histological and histochemical studies of oral cancer","volume":"27","author":"Johnson NW","year":"1977","journal-title":"Int Dent J"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890030103"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(88)90318-0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(88)80011-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140402"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400120060009"},{"key":"e_1_2_1_10_2","first-page":"27","volume-title":"Manual for staging of cancer","author":"American Joint Committee on Cancer","year":"1986"},{"key":"e_1_2_1_11_2","first-page":"229","article-title":"Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas","volume":"95","author":"Anneroth G","year":"1987","journal-title":"Scand J Dent Res"},{"key":"e_1_2_1_12_2","unstructured":"WoolgarJA.Lymph node metastasis in oral cancer. PhD thesis. The University of Liverpool 1994:."},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3790\/978-3-428-06689-6"},{"key":"e_1_2_1_14_2","first-page":"325","volume-title":"Practical statistics for medical research","author":"Altman DG","year":"1991"},{"key":"e_1_2_1_15_2","first-page":"322","volume-title":"Statistics for the social sciences with computer applications","author":"Walsh A","year":"1990"},{"key":"e_1_2_1_16_2","first-page":"237","article-title":"Pathological findings in clinically false\u2010negative and false\u2010positive neck dissections in oral cancer","volume":"76","author":"Woolgar JA","year":"1994","journal-title":"Ann R Coll Surg Eng"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80853-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1989.tb01339.x"},{"key":"e_1_2_1_19_2","first-page":"376","article-title":"Carcinoma. Grading and practical application","volume":"2","author":"Broders AC","year":"1926","journal-title":"Arch Pathol"},{"key":"e_1_2_1_20_2","first-page":"316","volume-title":"General pathology","author":"Walter JB","year":"1979"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90363-5"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841215)54:12<2995::AID-CNCR2820541230>3.0.CO;2-R"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890915)64:6<1195::AID-CNCR2820640606>3.0.CO;2-7"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90302-8"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90303-X"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110502"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0030-6665(20)32999-6","article-title":"Nodal metastases and prognosis in carcinoma of the oral cavity","volume":"5","author":"DiTroia JF","year":"1972","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_1_28_2","first-page":"28","volume-title":"Theory and practice of histological techniques","author":"Bancroft JD","year":"1990"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70173-D"},{"key":"e_1_2_1_30_2","first-page":"1473","article-title":"Tumor cell instability, diversification and progression to the metastatic phenotype: from oncogene to oncofetal expression","volume":"47","author":"Nicolson GL","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80457-9"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487509124667"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711600202"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060508"},{"key":"e_1_2_1_35_2","first-page":"29","article-title":"Tumor\u2010host interactions as prognostic factors in the histologic assessment of carcinomas","volume":"21","author":"Crissman JD","year":"1986","journal-title":"Pathol Ann"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480051601"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487309139720"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197402000-00006"},{"key":"e_1_2_1_39_2","first-page":"523","volume-title":"Histopathology of the skin","author":"Lever WF","year":"1990"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841867309131085"},{"key":"e_1_2_1_41_2","first-page":"881","article-title":"Grading of biopsies of laryngeal carcinomas by multiple criteria","volume":"4","author":"Fisher HR","year":"1975","journal-title":"Can J Otolaryngol"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197802000-00014"},{"key":"e_1_2_1_43_2","first-page":"17","volume-title":"Recent advances in histopathology. Number 15","author":"Underwood JCE","year":"1992"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00430.x"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711660409"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2880170603","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2880170603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T16:53:53Z","timestamp":1698252833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2880170603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1002\/hed.2880170603"],"URL":"https:\/\/doi.org\/10.1002\/hed.2880170603","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]}}}