{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:39:01Z","timestamp":1760981941122},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":10060,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six patients with malignant head and neck tumors are shown to have required electron microscopy for accurate diagnosis. In all of these tumors, there were ultrastructural features of cytodifferentiation that were not discernible by light microscopy, such as neurosecretory granules, desmosomes, cytoplasmic processes, tonofibrils, and myofilaments. Electron microscopy is helpful in the differential diagnosis of tumors in general, but its effectiveness is particularly apparent in small\u2010cell \u201cundifferentiated\u201d tumors such as neuroblastoma, rhabdomyosarcoma, Ewing's sarcoma, undifferentiated squamous\u2010cell carcinoma of the lymphoepithelioma type, and malignant lymphoma. It has also been helpful in the identification of amelanotic melanoma and spindle\u2010cell carcinoma.<\/jats:p>","DOI":"10.1002\/hed.2890010303","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:40:48Z","timestamp":1172000448000},"page":"202-212","source":"Crossref","is-referenced-by-count":6,"title":["Electron microscopy in the diagnosis of head and neck tumors"],"prefix":"10.1002","volume":"1","author":[{"given":"Hector","family":"Battifora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward L.","family":"Applebaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"310","article-title":"Histochemical and electron microscopic studies of eosinophilic granular cells (oncocytes) in tumors of the parotid gland","volume":"14","author":"Balogh K","year":"1965","journal-title":"Lab Invest"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197605)37:5<2275::AID-CNCR2820370518>3.0.CO;2-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/59.3.365"},{"key":"e_1_2_1_5_2","first-page":"65","article-title":"Fine structure of Crooke's hyaline change in the human pituitary gland","volume":"94","author":"De Cicco FA","year":"1972","journal-title":"Arch Pathol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1976.tb00842.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/61.5.690"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/53.5.555"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80120-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197501)35:1<148::AID-CNCR2820350121>3.0.CO;2-Q"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197012)26:6<1311::AID-CNCR2820260618>3.0.CO;2-C"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196902)23:2<390::AID-CNCR2820230214>3.0.CO;2-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197603)37:3<1334::AID-CNCR2820370314>3.0.CO;2-Y"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313027109071331"},{"key":"e_1_2_1_15_2","first-page":"763","article-title":"The pharyngeal pituitary gland","volume":"14","author":"Melchionna RH","year":"1938","journal-title":"Am J Pathol"},{"key":"e_1_2_1_16_2","first-page":"160","article-title":"Fine structural study of neuroblastoma, ganglioneuroblastoma and pheochromocytoma","volume":"86","author":"Misugi K","year":"1968","journal-title":"Arch Pathol"},{"key":"e_1_2_1_17_2","first-page":"81","article-title":"Rhabdomyosarcoma: an ultrastructural appraisal","volume":"7","author":"Morales AR","year":"1972","journal-title":"Pathol Annu"},{"key":"e_1_2_1_18_2","first-page":"43","article-title":"Electron microscopic and histochemical correlation of human anterior pituitary cells","volume":"59","author":"Paiz C","year":"1970","journal-title":"Am J Pathol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/65.5.623"},{"key":"e_1_2_1_20_2","first-page":"59","article-title":"Evidencia ultrastructural de la naturaleza linfoide del illamado \u201ctipo difuso de carcinoma indiferenciado de celulas peque\u00f1as del Tiroides\u201d: estudio de 2 casos","volume":"10","author":"Soto\u2010Velasco JM","year":"1972","journal-title":"Patolog\u00eda"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197701)39:1<131::AID-CNCR2820390123>3.0.CO;2-G"},{"key":"e_1_2_1_22_2","first-page":"287","article-title":"Fine structure of human pituitary adenoma","volume":"95","author":"Tomiyasu U","year":"1973","journal-title":"Arch Pathol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197604)37:4<1840::AID-CNCR2820370431>3.0.CO;2-U"},{"key":"e_1_2_1_23_3","first-page":"8","article-title":"Diagnostic electron microscopy of head and neck tumors","volume":"102","author":"Regezi JA","year":"1978","journal-title":"Arch Pathol Lab Med"}],"container-title":["Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2890010303","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2890010303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T01:36:01Z","timestamp":1699320961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2890010303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/hed.2890010303"],"URL":"https:\/\/doi.org\/10.1002\/hed.2890010303","archive":["Portico"],"relation":{},"ISSN":["0148-6403","1930-2398"],"issn-type":[{"value":"0148-6403","type":"print"},{"value":"1930-2398","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}