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Often the head and neck specialist is confronted with a child with one or more of these problems and must institute the appropriate therapy or decide on an avenue for further investigation. This paper outlines the major immunodeficiency states, discusses the immune defects thought to be responsible for the spectrum of clinical findings, and suggests a systematic approach to the evaluation of these difficult diseases. The recognition of immunodeficient individuals is an important step in their treatment so that adjunctive immunological therapy can be provided.<\/jats:p>","DOI":"10.1002\/hed.2890050206","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T20:49:53Z","timestamp":1172004593000},"page":"114-124","source":"Crossref","is-referenced-by-count":9,"title":["Immunodeficiency diseases: Head and neck manifestations"],"prefix":"10.1002","volume":"5","author":[{"given":"Jeffrey P.","family":"Harris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"South","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"163","article-title":"Hypogammaglobulemia in the United Kingdom","volume":"1","author":"Medical Research Council Working Party","year":"1969","journal-title":"Lancet"},{"key":"e_1_2_1_3_2","unstructured":"HobbsJR:Disturbances of the immunoglobulins. 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