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At the present time, Sj\u00f6gren's syndrome is defined as a lymphocyte\u2010mediated exocrinopathy but definition does little justice to the profound immunogenetic basis of the syndrome. This report presents a contemporary review of the lymphoepithelial lesion and the syndrome and presents a hypothesis of pathogenesis based on a graft vs host disease\u2010like disorder. The hypothesis incorporates the immunogenetic, immunoregulatory, and neoplastic aspects of Sj\u00f6gren's syndrome.<\/jats:p>","DOI":"10.1002\/hed.2890050211","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T20:49:53Z","timestamp":1172004593000},"page":"150-163","source":"Crossref","is-referenced-by-count":25,"title":["The pathology of head and neck tumors: The lymphoepithelial lesion and sj\u00f6gren's syndrome, part 16"],"prefix":"10.1002","volume":"5","author":[{"given":"John 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