{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:25:43Z","timestamp":1791912343687,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8234,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One hundred fourteen patients with advanced (stage III or IV) epidermoid carcinoma of the oral cavity, pharynx, larynx, and hypopharynx were treated by surgery and postoperative radiation therapy between 1975 and 1980. Twenty\u2010seven patients also received preoperative platinum\u2010containing chemotherapy. Sixteen patients developed second malignant neoplasms. The site of the second malignant neoplasm was in the esophagus in seven patients (44%), in the lung in six patients (37.5%), and at other sites in three patients (18.5%). Relapse of the head and neck cancer (at the primary site in 6 patients, in the neck in 11 patients, and at distant sites in 20 patients) appeared within the first 2 years in virtually all cases. In contrast, second malignant neoplasms have appeared at a steady rate of approximately 6% per year, for at least the first 4 years. Future efforts at improving the survival of patients with advanced head and neck cancer, therefore, must include strategies aimed at decreasing the incidence and the morbidity and mortality from second malignant neoplasms.<\/jats:p>","DOI":"10.1002\/hed.2890060306","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:14:34Z","timestamp":1172006074000},"page":"734-737","source":"Crossref","is-referenced-by-count":90,"title":["Second malignant neoplasms in patients successfully treated with multimodality treatment for advanced head and neck cancer"],"prefix":"10.1002","volume":"6","author":[{"given":"Bhadrasain","family":"Vikram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot W.","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Spiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90217-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060303"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060304"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100075204"},{"key":"e_1_2_1_6_2","unstructured":"Memorial Hospital for Cancer and Allied Diseases and the James Ewing Hospital of the City of New York: Statistical Report of End Results 1949\u20131957 Memorial Hospital for Cancer and Allied Diseases New York NY 1965."},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196103\/04)14:2<238::AID-CNCR2820140204>3.0.CO;2-F"},{"key":"e_1_2_1_8_2","first-page":"1358","article-title":"Multiple primary malignant tumors: Survey of literature and statistical study","volume":"16","author":"Warren S","year":"1932","journal-title":"Amer J Cancer"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195711\/12)10:6<1300::AID-CNCR2820100628>3.0.CO;2-2"}],"container-title":["Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2890060306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2890060306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:39:33Z","timestamp":1697848773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2890060306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/hed.2890060306"],"URL":"https:\/\/doi.org\/10.1002\/hed.2890060306","archive":["Portico"],"relation":{},"ISSN":["0148-6403","1930-2398"],"issn-type":[{"value":"0148-6403","type":"print"},{"value":"1930-2398","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}