{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:33:37Z","timestamp":1760888017449},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":8174,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurofibromatosis (von Recklinghausen's disease) is an autosomal dominant disease that affects one in 2,500\u20133,000 births. Because the head and neck is unique in its anatomical compartmentalization of the central and peripheral nervous systems, the potential for involvement of these areas with neurofibromas is substantial and accounts for a myriad of clinicopathologic presentations. In the present study, the incidence of involvement in the head and neck is 37%. We found 81% of the patients had caf\u00e9 au lait spots, 63% had positive family histories, and 66% had multiple cutaneous nodules. An incidence of malignant transformation was documented in 3.5% of the cases. Management of benign neurofibromatosis must be individualized for each patient and ranges from incisional biopsy to wide local excision. In every case, the risk of severe neurologic deficit must be weighed against the benefits of surgical resection, which is usually incomplete. Genetic counseling is advised for all patients with this disease, since no cure is available.<\/jats:p>","DOI":"10.1002\/hed.2890060407","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:13:39Z","timestamp":1172006019000},"page":"842-850","source":"Crossref","is-referenced-by-count":29,"title":["Neurofibromatosis of the head and neck"],"prefix":"10.1002","volume":"6","author":[{"given":"Dennis R.","family":"Maceri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith G.","family":"Saxon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"34","volume-title":"Uber die Multiplen Fibrome der Haut und ihre Beziehung Zuden Multiplen Neuromen","author":"von Recklinghausen F","year":"1882"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(70)80472-3"},{"key":"e_1_2_1_4_2","first-page":"10","volume-title":"A Clinicopathological and Genetic Study of Multiple Neurofibromatosis","author":"Crowe FW","year":"1956"},{"key":"e_1_2_1_5_2","first-page":"214","volume-title":"Surgery of the Upper Respiratory System","author":"Montgomery WW","year":"1979"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790470046011"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1973.01620200061017"},{"key":"e_1_2_1_8_2","first-page":"238","volume-title":"The Pathologic Basis of Disease","author":"Robbins S","year":"1979"},{"key":"e_1_2_1_9_2","first-page":"317","volume-title":"Tumors of the Head and Neck: Clinical and Pathological Considerations","author":"Batsakis JG","year":"1980"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/49.2.141"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1930.02220080104007"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1931.01160020081004"},{"key":"e_1_2_1_13_2","first-page":"15","volume-title":"Tumors of the Peripheral Nervous System; Atlas of Tumor Pathology","author":"Stout AP","year":"1949"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1952.01260010833013"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196308)16:8<1015::AID-CNCR2820160808>3.0.CO;2-I"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0503(81)80022-7"},{"key":"e_1_2_1_17_2","first-page":"1018","volume-title":"Roentgenologic Diagnosis","author":"Teplick JG","year":"1971"},{"key":"e_1_2_1_18_2","first-page":"1090","volume-title":"Textbook of Endocrinology","author":"Williams RH","year":"1981"},{"key":"e_1_2_1_19_2","first-page":"888","article-title":"von Recklinghausen neurofibromatosis and acute leukemia","volume":"130","author":"Reich SD","year":"1976","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790240046011"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-3840(77)80002-6"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1979.00790170037010"}],"container-title":["Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2890060407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2890060407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T19:22:19Z","timestamp":1697743339000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2890060407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["10.1002\/hed.2890060407"],"URL":"https:\/\/doi.org\/10.1002\/hed.2890060407","archive":["Portico"],"relation":{},"ISSN":["0148-6403","1930-2398"],"issn-type":[{"value":"0148-6403","type":"print"},{"value":"1930-2398","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}