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We report five cases of invasive aspergillosis of the nose and paranasal sinuses in profoundly neutropenic patients treated with broad spectrum antibiotics. Both <jats:bold><jats:italic>Aspergillus fumigatus<\/jats:italic><\/jats:bold> and <jats:bold><jats:italic>Aspergillus flavus<\/jats:italic><\/jats:bold> were cultured and identified in this entity. Awareness of this disease and early diagnosis made by culture and histologic examinations of biopsy material are essential. Treatment consisting of amphotericin B therapy and surgical debridement can be effective in eradicating this form of aspergillosis.<\/jats:p>","DOI":"10.1002\/hed.2890080205","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:18:32Z","timestamp":1172006312000},"page":"83-90","source":"Crossref","is-referenced-by-count":24,"title":["Aspergillosis of the nose and paranasal sinuses in neutropenic patients at an oncology center"],"prefix":"10.1002","volume":"8","author":[{"given":"Zvi","family":"Landoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coleman","family":"Rotstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Shedd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197003000-00002"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-5-539"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-3-345"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90208-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.2.230"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113427"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/archinte.1971.00310220049004","article-title":"Aspergillus infection complicating cardiac transplantations: report of 5 cases","volume":"128","author":"Gurwith MJ","year":"1971","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/72.4.617"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408368009106444"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1001\/jama.1976.03260300037029","article-title":"Aspergillus infections in cancer patients: association with fireproofing materials in a new hospital","volume":"235","author":"Aisner J","year":"1976","journal-title":"JAMA"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408368009106445"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(79)80003-4"},{"key":"e_1_2_1_14_2","first-page":"62","article-title":"Aspergillosis of the maxillary sinus","volume":"57","author":"Titche LL","year":"1978","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-117X(82)80027-9"},{"key":"e_1_2_1_16_2","first-page":"44","article-title":"Aspergillosis of the paranasal sinuses","volume":"62","author":"Sundaram K","year":"1983","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_1_17_2","first-page":"6","article-title":"Aspergillosis of the paranasal sinuses","volume":"57","author":"Smolansky SJ","year":"1978","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540891003"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198207000-00010"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198005000-00003"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80774-4"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80086-4"},{"key":"e_1_2_1_23_2","first-page":"33","article-title":"Increased recovery of Aspergillus flavus from respiratory specimens during hospital construction","volume":"125","author":"Sarubbi FA","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<411::AID-CNCR2820530308>3.0.CO;2-E"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198501000-00009"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-1-4"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/82.5.597"},{"key":"e_1_2_1_28_2","first-page":"1","volume-title":"Infections in the Abnormal Host","author":"Grieco MH","year":"1980"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90414-4"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.244.8.814"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-6-777"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198410183111617"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","unstructured":"RhameFS StreifelAJ KerseyJHJr McGlavePB:Extrinsic risk factors for pneumonia in the patient at high risk of infection. 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