{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:38:13Z","timestamp":1790822293863,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":7503,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synchronously administered cis\u2010platinum (cis\u2010DDP) and radiation therapy have been used to treat unresectable squamous cell carcinomas of the head and neck. The purpose of this study was to evaluate the efficacy and tolerance of preoperative adjuvant cis\u2010DDP plus radiation therapy in operable stage III and IV head and neck cancers. Radiation therapy (4,500 rad) was delivered in 180\u2010rad daily fractions. Cis\u2010DDP (20 mg\/M<jats:sup>2<\/jats:sup>) was given before radiotherapy on days 1\u20134 and 21\u201324. Eighteen patients began therapy; 16 completed the combined regimen. Toxicity included stomatitis (3) and WBC below 2,500\/mm<jats:sup>3<\/jats:sup> (2). One patient died from therapy of a cerebrovascular accident. Sixteen patients (89%) achieved a complete or partial response to therapy. Complete responses were observed in 13 of 18 primary tumors (72%), and in all three patients with cervical lymphadenopathy. Complete responses were noted for lesions of the nasopharynx, oral cavity, pharynx, hyopharynx, and larynx, for all histologic grades of squamous cell carcinoma. Twelve patients underwent curative surgery. Site\u2010related morbidity occurred in two patients (15%) and a third patient developed postoperative pneumonia. Five of 10 resected primary tumors with preoperative complete responses were pathologically negative for tumor. Concurrent bolus cis\u2010DDP and radiation therapy are welltolerated and result in impressive tumor reduction. Morbidity after subsequent curative surgery is low, and histologic complete responses are frequent. Trials of this promising combined modality approach to advance operable cancers of the head and neck, when compared to other treatment sequences, appear warranted.<\/jats:p>","DOI":"10.1002\/hed.2890080306","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:18:05Z","timestamp":1172006285000},"page":"159-164","source":"Crossref","is-referenced-by-count":19,"title":["Preoperative simultaneously administered cis\u2010platinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck"],"prefix":"10.1002","volume":"8","author":[{"given":"Gus J.","family":"Slotman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvin R.","family":"Glicksman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Doolittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis A.","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197702)39:2 <868::AID-CNCR2820390724>3.0.CO;2-N"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90217-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0030-6665(20)32353-7","article-title":"The treatment of patients with stage IV squamous cell carcinoma of the head and neck","volume":"13","author":"Ucmakli A","year":"1980","journal-title":"Otolarynol Clin North Am"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90216-0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(70)80016-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90207-X"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90208-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90419-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1116::AID-CNCR2820350415>3.0.CO;2-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197907)44:1<19::AID-CNCR2820440104>3.0.CO;2-R"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830615)51:12<2168::AID-CNCR2820511204>3.0.CO;2-H"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90417-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930150114"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100090423"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790410035009"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810501)47:9<2259::AID-CNCR2820470926>3.0.CO;2-Q"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810901)48:5<1106::AID-CNCR2820480510>3.0.CO;2-Q"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(75)80003-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841101)54:9<2009::AID-CNCR2820540938>3.0.CO;2-3"},{"key":"e_1_2_1_21_2","first-page":"75","article-title":"Chemotherapy in head and neck cancer","volume":"308","author":"Hong WK","year":"1983","journal-title":"Medical Intelligence"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90667-9"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90680-1"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90673-4"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90672-2"},{"key":"e_1_2_1_26_2","first-page":"585","article-title":"Therapeutic potentiation in a mouse mammary tumor and an intracerebral rat brain tumor by combined treatment with cis\u2010dichlorodiammineplatinum (II) and radiation","volume":"7","author":"Douple EB","year":"1977","journal-title":"J Clin Hematol Oncol"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90669-2"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90671-0"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90670-9"},{"key":"e_1_2_1_30_2","first-page":"160","article-title":"Cis\u2010Platinum (DDP) with radiation therapy (RT) for locally unresectable head and neck cancer","volume":"2","author":"Haselow RE","year":"1983","journal-title":"Cancer Proc ASCO"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(83)90231-3"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198212000-00014"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(79)90675-8"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800101)45:1<11::AID-CNCR2820450104>3.0.CO;2-E"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90380-5"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(82)90419-6"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(84)90381-7"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1981.00790470038009"}],"container-title":["Head &amp; Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhed.2890080306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.2890080306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:48:53Z","timestamp":1697834933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.2890080306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1002\/hed.2890080306"],"URL":"https:\/\/doi.org\/10.1002\/hed.2890080306","archive":["Portico"],"relation":{},"ISSN":["0148-6403","1930-2398"],"issn-type":[{"value":"0148-6403","type":"print"},{"value":"1930-2398","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}