{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T09:44:03Z","timestamp":1769420643842,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":7018,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[1987,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphocyte phenotypes were identified by monoclonal antibodies and avidin\u2010biotin peroxidase reagents and enumerated in tumor tissue removed from 26 patients with head and neck cancer. T lymphocytes (T11) were the predominate phenotype at the tumor margin, with twice as many helper\/inducer (T4) as suppressor\/cytotoxic (T8) lymphocytes. Patients with Stage II and III carcinoma of the glottis, tongue, and hypopharynx had significantly increased numbers of all T lymphocyte phenotypes when compared to patients with Stage IV disease, thus achieving statistical significance for the T11 and T8 phenotypes. All patients were followed for 2.5 years; those patients who remained free of malignant disease had an increased number of all T lymphocyte phenotypes compared to patients with recurrent malignancy, but this did not achieve statistical significance. Thus, increased numbers of 111 positive lymphocytes of both the T4 and T8 subsets in the tissue at the margins of head and neck tumors were associated with a more favorable prognosis. These results support the concept of an immunologic reaction at the tumor margin, which may be limiting the growth and spread of tumor.<\/jats:p>","DOI":"10.1002\/hed.2890090503","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:26:28Z","timestamp":1172006788000},"page":"265-271","source":"Crossref","is-referenced-by-count":20,"title":["Lymphocyte phenotypes at tumor margins in patients with head and neck cancer"],"prefix":"10.1002","volume":"9","author":[{"given":"Min","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce S.","family":"Rabin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irvin L.","family":"Paradis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"517","article-title":"Dinitrochlorobenzene skin sensitization and peripheral lymphocyte count: predictors of survival in head and neck cancer","volume":"85","author":"Maisel RH","year":"1976","journal-title":"Ann Otol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(77)90380-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/019459988008800116","article-title":"Correlation of preoper\u2010ative immunologic test results with recurrence in patients with head and neck cancer","volume":"88","author":"Ryan RE","year":"1980","journal-title":"Otolaryngol Head Neck Surg"},{"key":"e_1_2_1_5_2","first-page":"756","article-title":"Immunologic response in cancer patients","volume":"121","author":"Solwey AC","year":"1965","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988409200402"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108203050804"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(85)90236-8"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198405000-00022"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840601)53:11<2456::AID-CNCR2820531116>3.0.CO;2-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910350610"},{"key":"e_1_2_1_12_2","first-page":"4053","article-title":"Lymphoid cell sub\u2010populations infiltrating into antologous rat tumors undergoing rejection","volume":"4","author":"Ishi Y","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_2","first-page":"415","article-title":"Mononuclear cells in malignant and benign human breast tissue","volume":"107","author":"Giorno R","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_14_2","first-page":"113","article-title":"Lymphocytes at tumor margins and extent of disease in lung cancer","volume":"127","author":"Paradis IL","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_15_2","first-page":"25","volume-title":"Manual for Staging of Cancer","author":"American Joint Committee for Staging of Cancer","year":"1983"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/32.4.6368677"},{"key":"e_1_2_1_17_2","first-page":"228","article-title":"Distribution and quantitation of T lymphocyte subsets in human tonsils as defined by monoclonal antibodies","volume":"107","author":"Si L","year":"1983","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_18_2","first-page":"449","article-title":"The use of monoclonal anti\u2010T cell antibodies to study T cell imbalances in human disease","volume":"45","author":"Bach AM","year":"1981","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4049\/jimmunol.128.1.16","article-title":"Human T cell subpopulation defined by a monoclonal antibody. 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