{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:17:40Z","timestamp":1789967860899,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Head Neck"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Between March 1973 and June 1979, patients with advanced operable squamous cell carcinoma of the supraglottic larynx or hypopharynx were randomly allocated to receive either preoperative radiation therapy (5,000 rad) or postoperative radiation therapy (6.000 rad). Patients with oral cavity or oropharynx lesions were randomly assigned either preoperative radiation, postoperative radiation, or definitive radiatio therapy (6,500\u20137,000 rad), with surgery reserved for slavage if residual disease was present 6 weeks after completion of irradiation. Three hundred twenty patients were evaluable with a median follow\u2010up of 60 months. Based on results in 277 patients across all four region combined, locoregional control was significantly better for patients assigned to receive psotoperative radiation therapy (65%) compared with those assigned to receive preoperative radiation therapy (48%,<jats:italic>P<\/jats:italic>=0.04). This was due to higher rate of both persistent and recurrent local and regional disease in the preoperative group. Survival also showed a trend to be better in the postoperative group (38%) compared with the preoperative group (38%) compared with the preoperative group (33%,<jats:italic>P<\/jats:italic>= 0.10). Rates of severe surgical and radiation therapy complications were similar overall. Forty\u2010three patients were evalauble for each of the three treatment regimens assigned to patients with oral cavity or oropharynx lesions. Due to the small number of patients available for this portion of the trial, the observed differences for overall survival (4\u2010year percentage 33% overall; 30% preoperative, 36% postoperative, 33% definitive radiation therapy) and for locoregional control (45% overall; 43% preoperative, 52% postoperative, 38% definitive radiation therapy) were not statistically significant. The use of definitive radiation therapy with surgical rescue as an ethically justified alternative treatment for these tumors remains a question for further research.<\/jats:p>","DOI":"10.1002\/hed.2890100105","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:27:56Z","timestamp":1172006876000},"page":"19-30","source":"Crossref","is-referenced-by-count":279,"title":["Combined radiation therapy and surgery in the management of advanced head and neck cancer: Final report of study 73\u201303 of the radiation therapy oncology group"],"prefix":"10.1002","volume":"10","author":[{"given":"Simon","family":"Kramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Gelber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Snow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"Marcial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis D.","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence W.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"397","article-title":"Planned combination of surgery and radiation in treatment of advanced primary head and neck cancers","volume":"77","author":"MacComb WS","year":"1957","journal-title":"Am J Roentgenol Radium Ther Nud Med"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/73.6.845"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197109000-00012"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1163::AID-CNCR2820350422>3.0.CO;2-C"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197702)39:2 <862::AID-CNCR2820390723>3.0.CO;2-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197005000-00011"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060303"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060304"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060305"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2890060306"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197704)39:4<1445::AID-CNCR2820390415>3.0.CO;2-6"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2307\/2530374"},{"key":"e_1_2_1_15_2","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J Roy Statist Soc (Series B)"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820315)49:6<1297::AID-CNCR2820490637>3.0.CO;2-J"},{"key":"e_1_2_1_18_2","first-page":"213","article-title":"Methotrexate and radiation therapy in the treatment of advanced squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx, and hypopharynx","volume":"4","author":"Kramer S","year":"1975","journal-title":"Can J Otolaryngol"}],"container-title":["Head &amp; 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