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Forty\u2010three patients were not treated by induction chemotherapy; 95 patients received preoperative chemotherapy with bleomycin as a single agent; 98 patients received three preoperative courses of vincristine, methotrexate, bleomycin, or endoxan, and 46 patients were treated by three courses of induction chemotherapy consisting of cisplatin, bleomycin, methotrexate, or 5\u2010fluorouracil. Seventy\u2010two patients received less than 150 mg of bleomycin and 17 patients received only one or two cycles of multiple\u2010agent chemotherapy. Survivals were higher when multiple\u2010agent chemotherapy was employed as compared with single\u2010agent induction chemotherapy. Further prospective investigations are necessary to confirm that induction chemotherapy enhances survival in pyriform sinus cancers.<\/jats:p>","DOI":"10.1002\/hed.2890100606","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T21:26:10Z","timestamp":1172006770000},"page":"396-401","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of survival after induction chemotherapy in pyriform sinus carcinoma"],"prefix":"10.1002","volume":"10","author":[{"given":"Daniel","family":"Brasnu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Menard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Bassot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7sois","family":"Janot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Laccourreye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90576-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198204000-00001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198412000-00011"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600216"},{"key":"e_1_2_1_6_2","first-page":"1","article-title":"Experimental evaluation of potential anti\u2010cancer agents on the criteria and kinetics associated with \u201ccurability\u201d of experimental leukemia","volume":"35","author":"Skipper HE","year":"1964","journal-title":"Cancer Chemother Rep"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197305102881905"},{"key":"e_1_2_1_8_2","first-page":"439","article-title":"Rationale for the use of alternating non\u2010cross\u2010resistant chemotherapy","volume":"66","author":"Goldie JH","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_9_2","first-page":"411","article-title":"R\u00e9sultats pr\u00e9liminaires d'une polychimioth\u00e9rapie pr\u00e9\u2010op\u00e9ratoire dans les \u00e9pith\u00e9liomas du pharyngolarynx: oncovin, m\u00e9thotrexate et bl\u00e9omycine","volume":"98","author":"Laccourreye H","year":"1981","journal-title":"Ann Otolaryngol"},{"key":"e_1_2_1_10_2","first-page":"428","article-title":"Adjuvant cisplatinum and 5\u2010fluorouracile 96 hour infusion in previously untreated epidermoid cancer of the head and neck (abstract)","volume":"22","author":"Al Sarraf M","year":"1981","journal-title":"ASCO"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801101)46:9<1974::AID-CNCR2820460913>3.0.CO;2-A"},{"key":"e_1_2_1_12_2","first-page":"171","article-title":"Bleomycin as a complement in the treatment of pharynx and larynx carcinomas: a three\u2010year assessment","volume":"19","author":"Laccourreye H","year":"1975","journal-title":"Gann Monogr Cancer Res"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0030-6665(20)32352-5","article-title":"Treatment of previously untreated stage III and IV squamous cell carcinoma of the head and neck","volume":"13","author":"Hong WK","year":"1980","journal-title":"Otolaryngol Clin North Am"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850301)55:5<1123::AID-CNCR2820550530>3.0.CO;2-8"},{"key":"e_1_2_1_15_2","first-page":"443","article-title":"Monochimioth\u00e9rapie par la bl\u00e9omycine dans les \u00e9pith\u00e9liomas du pharyngolarynx. 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