{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:03:22Z","timestamp":1792249402572,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020413","name":"Rakuten Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ASP\u20101929 photoimmunotherapy\u2014cetuximab conjugated to IRDye 700DX and red light (690\u2009nm) for localized drug activation\u2014results in rapid, selective cell killing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This phase Ib\/II open\u2010label study evaluated ASP\u20101929 photoimmunotherapy plus pembrolizumab in patients with recurrent\/metastatic HNSCC (\u2265\u20091 accessible lesion, PD\u2010L1 combined positive score \u2265\u20091, ineligible for standard locoregional therapy). Primary objectives were safety\/tolerability and objective response rate (ORR). Secondary objectives included overall survival (OS) and progression\u2010free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen patients (median age 63\u2009years, 74% male) comprised the photoimmunotherapy\u2010evaluable population. The confirmed ORR was 27.8% (95% CI 9.7\u201353.5); four of five responders had complete responses (95% CI, 6.4\u201347.6). Median OS was 25.6\u2009months (95% CI, 14.6\u2013not evaluable); median PFS was 2.9\u2009months (95% CI, 1.4\u201314.6). The most common serious adverse reactions were dysphagia and tongue edema (each\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092; 10.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ASP\u20101929 photoimmunotherapy plus pembrolizumab was generally tolerable, with promising efficacy in patients with recurrent\/metastatic HNSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70014","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T09:18:17Z","timestamp":1756113497000},"page":"160-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Safety and Efficacy Findings From a Phase Ib\/\n                    <scp>II<\/scp>\n                    Study of\n                    <scp>ASP<\/scp>\n                    \u20101929 Photoimmunotherapy With Pembrolizumab in Recurrent and\/or Metastatic Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"48","author":[{"given":"David M.","family":"Cognetti","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Thomas Jefferson University  Philadelphia Pennsylvania USA"},{"name":"Sidney Kimmel Comprehensive Cancer Center Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Thomas Jefferson University  Philadelphia Pennsylvania USA"},{"name":"Sidney Kimmel Comprehensive Cancer Center Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Johnson","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Comprehensive Cancer Center Thomas Jefferson University  Philadelphia Pennsylvania USA"},{"name":"Department of Medical Oncology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Division of Diagnostic Imaging University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Y.","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Civantos","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Miller School of Medicine, University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Olazagasti","sequence":"additional","affiliation":[{"name":"Medical Oncology Sylvester Comprehensive Cancer Center, University of Miami  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Valentino","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Bryan","family":"Bell","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, Radiation Oncology, and Clinical Programs Providence Cancer Institute  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Mannion","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Van Abel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine A.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Dong","sequence":"additional","affiliation":[{"name":"Global Data and Analytics, Rakuten Medical, Inc  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H.","family":"Thorne","sequence":"additional","affiliation":[{"name":"Pre\u2010Clinical Research and Development, Rakuten Medical, Inc  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Rakuten Medical, Inc  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Gillenwater","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1715715"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30933"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0458"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00224-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.11.824"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.011"},{"key":"e_1_2_12_10_1","unstructured":"National Comprehensive Cancer Network \u201cHead and Neck Cancers. 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