{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:46:43Z","timestamp":1782748003006,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>HPV\u2010negative head and neck squamous cell carcinoma (HNSCC) patients can face prolonged gastrostomy tube (g\u2010tube) dependence, affecting quality of life and delaying treatment. Existing models lack key health metrics like sarcopenia; this study develops a risk model to enhance preoperative assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study analyzed 265 HNSCC patients. Sarcopenia was assessed via cervical paraspinal skeletal muscle mass (C3) on CT scans. Patients requiring g\u2010tube support\u2009&gt;\u200928\u2009days were identified. Risk models were developed and compared to the PEG Score. A 50\u2010patient validation cohort assessed model performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Key predictors included male sex, sarcopenia, prior radiotherapy, and adjuvant therapy. Logistic regression (LR) model had the highest AUC (0.78); followed by Recursive Partitioning analysis (RPA) model (0.76), both outperforming the PEG Score (0.67). RPA model maintained superior accuracy in validation (AUC\u2009=\u20090.79).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RPA model outperformed PEG Score, offering a more precise risk tool for preoperative planning and early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70015","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:27:01Z","timestamp":1755077221000},"page":"114-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fuel for Recovery: Predicting G\u2010Tube Dependence in\n                    <scp>HPV<\/scp>\n                    \u2010Negative Operable\n                    <scp>HNSCC<\/scp>"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2369-8680","authenticated-orcid":false,"given":"Marie\u2010Michelle","family":"McNicoll","sequence":"first","affiliation":[{"name":"Undergraduate Medical Education McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex M.","family":"Mlynarek","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hier","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3218-2668","authenticated-orcid":false,"given":"Nader","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Casola","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition\u2014Jewish General Hospital McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Bouganim","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashayar","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tsien","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Shenouda","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Sultanem","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology McGill University  Montr\u00e9al Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8880-805X","authenticated-orcid":false,"given":"Marco A.","family":"Mascarella","sequence":"additional","affiliation":[{"name":"Department of 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