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Their characterization in nasopharyngeal carcinoma (NPC) is of interest due to its viral etiology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      NPC tumors from patients treated at Peter MacCallum Cancer Centre (PMCC; 2000\u20132017) were examined for CD103\n                      <jats:sup>+<\/jats:sup>\n                      , CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, and PD\u2010L1 abundance, correlated with survival, and underwent NanoString transcriptomic analysis. Additional cohorts from Hong Kong and Singapore were assessed for CD103\n                      <jats:sup>+<\/jats:sup>\n                      intra\u2010tumoral immune cell (ITIC) abundance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 141 PMCC patients, 29% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930\/103) of NPC tumors had high CD103\n                      <jats:sup>+<\/jats:sup>\n                      ITIC (defined as \u2265\u200930%) linked with\n                      <jats:italic>T<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>RM<\/jats:italic>\n                      <\/jats:sub>\n                      gene expression, immune checkpoints, and upregulated pathways in T\u2010cell activation. Abundance of CD103\n                      <jats:sup>+<\/jats:sup>\n                      ITIC was not associated with improved survival (PMCC: HR\u2009=\u20090.9, 95% CI: 0.4\u20132.1) across all cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Despite similarities to other virally driven tumors, CD103\n                      <jats:sup>+<\/jats:sup>\n                      ITIC abundance was not prognostic in NPC, highlighting the need for better characterization of T\n                      <jats:sub>RMs<\/jats:sub>\n                      subpopulations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70026","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T08:51:07Z","timestamp":1756889467000},"page":"362-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Examining CD103\n                    <sup>+<\/sup>\n                    Tissue\u2010Resident Memory T Cells in Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"48","author":[{"given":"Alesha A.","family":"Thai","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Young","sequence":"additional","affiliation":[{"name":"Cancer Research Division Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Bressel","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Centre for Biostatistics and Clinical Trials Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte B. 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