{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:19:07Z","timestamp":1769635147066,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T00:00:00Z","timestamp":1756944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This multicenter study examines the impact of stratified surgical margins on treatment outcomes in oral SCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Margins were stratified into 1\u2009mm increments from 0 to \u2265\u20095\u2009mm. Outcomes included local recurrence, overall and disease\u2010specific survivals. Sub\u2010analyses assessed the impact of margin status by risk factors, oral subsites, and peripheral versus deep margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2737 patients, \u2265\u20092 to &lt;\u20093\u2009mm margins were associated with improved outcomes compared to 0\u2009mm. Further benefits were observed in the \u2265\u20094 to &lt;\u20095\u2009mm group. The differences between these two groups were not statistically significant. Improved outcomes were observed with \u2265\u20092\u2009mm deep margins, but not for peripheral margins. High\u2010risk tumors had better overall and disease\u2010specific survivals with \u2265\u20092\u2009mm margins. Subsites of the tongue, palate, mandible, and floor of the mouth had improved local control with \u2265\u20092\u2009mm margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Margins beyond 4\u2009mm do not confer additional oncological benefit, while achieving \u2265\u20092\u2009mm, especially in deep margins or high\u2010risk tumors, is critical for optimal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70029","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:12:10Z","timestamp":1756977130000},"page":"372-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Stratified Surgical Margins on Survival Outcomes in Oral Cavity Squamous Cell Carcinoma: A Multicenter 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