{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:34:22Z","timestamp":1776332062450,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Though neoadjuvant chemotherapy (NACT) has not improved survival in oral cancers, its role in tongue cancer remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of patients with locally advanced oral tongue cancer (Stage III\u2013IVB) to assess response rates, mandibular preservation, and surgical extent post\u2010NACT, along with recurrence and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 72 patients, 20 (27.8%) received NACT, while 52 (72.2%) underwent upfront surgery. In the NACT group, 15 (75%) received TPF chemotherapy for a median of 3\u2009cycles. One patient (5%) had a complete response, and 13 (65%) had a partial response. The clinical benefit rate was 85%. Tumor downstaging occurred in 14 (70%) patients, with 6 (42.9%) requiring less extensive surgery. The mandibular preservation rate was 75%. The pathological complete response was 10%. Local and distant control rates, disease\u2010free survival, and overall survival were comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite its retrospective design and small sample size, this study suggests that NACT can downstage tumors, improve response rates, and enable less extensive surgery in locally advanced tongue cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70035","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:58:46Z","timestamp":1757408326000},"page":"416-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neoadjuvant Chemotherapy Followed by Surgery\u2014A Promising Strategy to Reduce Morbidity in Locally Advanced Tongue Cancer"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-921X","authenticated-orcid":false,"given":"G. 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