{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:45:37Z","timestamp":1769672737399,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1K08CA293255\u20100"],"award-info":[{"award-number":["1K08CA293255\u20100"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cystic lateral neck masses in adults commonly represent nodal metastases from HPV\u2010associated oropharyngeal squamous cell carcinoma (OPSCC) or benign lesions. Because cystic lesions are relatively acellular, fine\u2010needle aspiration (FNA) is often non\u2010diagnostic. HPV circulating tumor DNA (ct\u2010DNA) may aid diagnosis in these cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a two\u2010institution retrospective review of patients with cystic neck masses and non\u2010diagnostic FNA who underwent pre\u2010treatment HPV ct\u2010DNA testing. Sensitivity, specificity, and predictive values were calculated based on final pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010two patients were included. HPV ct\u2010DNA was positive in 20\/32 (62.5%) cases, all of which were HPV\u2010associated OPSCC. Four patients with negative HPV ct\u2010DNA were ultimately diagnosed with HPV\u2010associated OPSCC (sensitivity: 83%, specificity: 100%, PPV: 100%, NPV: 67%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HPV ct\u2010DNA demonstrated high specificity and may complement standard workup in adult cystic neck masses with non\u2010diagnostic FNA. Positive HPV ct\u2010DNA results should prompt further evaluation for HPV\u2010associated OPSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70060","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T07:36:21Z","timestamp":1759822581000},"page":"543-548","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy of\n                    <scp>HPV<\/scp>\n                    Circulating Tumor\n                    <scp>DNA<\/scp>\n                    Following Non\u2010Diagnostic\n                    <scp>FNA<\/scp>\n                    of a Cystic Lateral Neck Mass"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-4940","authenticated-orcid":false,"given":"Michael R.","family":"Papazian","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie D.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-1791","authenticated-orcid":false,"given":"Kyle","family":"Mannion","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8621-6168","authenticated-orcid":false,"given":"Meghan","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery West Virginia University Health Sciences Center  Morgantown West Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-4417","authenticated-orcid":false,"given":"Michael C.","family":"Topf","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Vanderbilt University Medical Center  Nashville Tennessee 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