{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:29:11Z","timestamp":1770812951997,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinical tolerance and performance of personalized porous titanium implants (PTIs) used on the craniofacial skeleton.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>International multicentric study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients who received PTIs during a 7\u2010year period were included. The primary outcome was the presence of the PTI at the last visit without surgical revision. Local and systemic infections, implant removal, fixation device failure, exposure, re\u2010intervention, and adverse events were assessed at the last visit. We also analyzed risk factors for implant failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety patients (36, 33, and 21 in the skull, midface, and mandible groups, respectively) with 97 craniofacial PTIs were followed up for a mean of 2.46\u2009years after surgery. At the last visit, 73 patients (81.1%) still had their implant. Overall success rates were 97.2%, 78.8%, and 57.1% for the skull, midface, and mandible groups, respectively. Most complications and implant removals occurred in the mandible group and irradiated patients. On the whole cohort, radiotherapy was associated with a\u2009&gt;\u20094\u2010time higher risk of failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrated an acceptable PTIs overall benefit\u2013risk profile. However, we recommend a careful selection of patients, taking into account anatomical site and treatment history.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70068","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T07:35:39Z","timestamp":1760600139000},"page":"747-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patient\u2010Specific Cranio\u2010Facial Porous Titanium Implants: A Multicentric Cohort Study"],"prefix":"10.1002","volume":"48","author":[{"given":"Thomas","family":"Schouman","sequence":"first","affiliation":[{"name":"Service de Chirurgie Maxillo\u2010Faciale Sorbonne Universite, AP\u2010HP, Hopital Pitie\u2010Salpetriere  Paris France"},{"name":"Arts et Metiers Sciences &amp; Technologies Institut de Biomecanique Humaine Georges Charpak  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herve","family":"Benateau","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo\u2010Faciale, Plastique et Reconstructrice, Chirurgie Orale et Implantologie Centre Hospitalier Universitaire de Caen  Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Le Clerc","sequence":"additional","affiliation":[{"name":"Service d'ORL AP\u2010HP, Hopital Lariboisiere \u2010 Fernand\u2010Widal  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marouane","family":"Talbi","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Maxillo\u2010Faciale CHR de Metz\u2010Thionville, Hopital de MERCY  Metz France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Roualdes","sequence":"additional","affiliation":[{"name":"Service de Neurochirurgie CHU Nantes, Hopital Nord Laennec  Nantes 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