{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:59:41Z","timestamp":1774497581637,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n To evaluate the clinical outcomes and patterns of failure in patients with paranasal sinus cancer treated by proton therapy during 2013\u20132022.<\/jats:p>\n <\/jats:sec>\n \n Methods and Materials<\/jats:title>\n \n This retrospective study included 88 patients with newly diagnosed nonmetastatic paranasal sinus cancer treated by proton therapy at a tertiary academic cancer center from August 2013 to November 2022. Fifteen patients were treated by three\u2010dimensional conformal proton technique (\n 3DCPT<\/jats:styled-content>\n ) and 73 patients were treated by intensity modulated proton therapy (\n IMPT<\/jats:styled-content>\n ). The main outcomes were the long\u2010term toxicity, patterns of failure and survival outcomes, including cumulative incidence of local or regional failures (\n LRF<\/jats:styled-content>\n ) and overall survival (\n OS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median (interquartile range [\n IQR<\/jats:styled-content>\n ]) follow\u2010up time for the overall group was 57.3 (38.5\u201382.6) months. Acute grade 3 radiation dermatitis and late grade 3 nasal congestion occurred significantly more frequently in the\n 3DCPT<\/jats:styled-content>\n group compared to the\n IMPT<\/jats:styled-content>\n group (20.0% vs. 4.1%,\n p<\/jats:italic>\n \u2009=\u20090.008; 33.3% vs. 5.6%,\n p<\/jats:italic>\n \u2009=\u20090.004, respectively). By the last follow\u2010up, 33 patients had developed treatment failures. A total of 21 patients (23.9%) developed local failures, 14 were considered in\u2010field failure; 4 were marginal; 3 were out\u2010of\u2010field failure. The 5y\u2010cumulative incidence of\n LRF<\/jats:styled-content>\n and\n OS<\/jats:styled-content>\n rate of the overall group were 25% [95% confidence interval (\n CI<\/jats:styled-content>\n ), 16\u201335] and 79.4% (70.2\u201389.8), respectively. There were no statistically significant differences following\n 3DCPT<\/jats:styled-content>\n and\n IMPT<\/jats:styled-content>\n in cumulative incidence of\n LRF<\/jats:styled-content>\n and\n OS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Proton therapy yielded excellent therapeutic outcomes in the management of paranasal sinus cancer.\n IMPT<\/jats:styled-content>\n holds significant potential in enhancing the therapeutic ratio in paranasal sinus cancer and warrants further exploration in clinical settings.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.70078","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:47:56Z","timestamp":1761022076000},"page":"774-781","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proton Therapy for Paranasal Sinus Cancer: Clinical Outcomes and Patterns of Failure"],"prefix":"10.1002","volume":"48","author":[{"given":"Caineng","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou China"},{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teeradon","family":"Treechairusame","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"},{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeem","family":"Riaz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean M.","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-6246","authenticated-orcid":false,"given":"Daphna Y.","family":"Gelblum","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achraf","family":"Shamseddine","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-7967","authenticated-orcid":false,"given":"Marc A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4496-906X","authenticated-orcid":false,"given":"Jennifer R.","family":"Cracchiolo","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Ganly","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan L.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-2571","authenticated-orcid":false,"given":"Lara A.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21752"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104737"},{"key":"e_1_2_9_4_1","unstructured":"NCCN Guidelines Version 2 (2025) http:\/\/www.nccn.org\/."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-023-02296-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.05.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32776"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.08.028"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27381"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28082"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.044"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjr\/tqae175"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.02.048"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11816"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cai2.70003"}],"container-title":["Head & Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:00:15Z","timestamp":1770789615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,20]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/hed.70078"],"URL":"https:\/\/doi.org\/10.1002\/hed.70078","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,20]]},"assertion":[{"value":"2025-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}