{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:47:12Z","timestamp":1773200832187,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Head and neck paragangliomas (HNPGLs) are rare neuroendocrine tumors and often arise in the head and neck. Due to their localization, the tumor and its surgical treatment pose a risk for cranial nerve impairments. Few studies have focused on the health\u2010related quality of life (HRQOL) in patients with HNPGLs and their relation to tumor localization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009125) treated with primary surgery for HNPGLs between 2006 and 2023, clinical data was obtained. Long\u2010term QOL was assessed with the validated German version of the EORTC QLQ\u2010H&amp;N43 with a mean follow\u2010up since surgery of 6.0\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most common were carotid body PGLs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978; 62.4%) including Shamblin I (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), II (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942) and III (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099) along jugular (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931; 24.8%) and vagal (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910; 8.0%) tumors. In the QLQ\u2010H&amp;N43, the scales fear of progression (41.2), coughing (33.9), neurological problems (22.4), sexuality (21.4), and swallowing (21.2) showed the highest mean scores. Jugular and vagal tumors showed higher symptom levels compared to carotid body tumors, especially Shamblin I.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgical treatment of PGLs may lead to significant impairments in physical and psychological domains, especially in larger carotid body, vagal and jugular tumors. Structured pre\u2010 and postoperative cranial nerve examinations and interprofessional support should be provided to mitigate postoperative QOL reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70084","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:56:49Z","timestamp":1762423009000},"page":"941-949","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life After Surgical Treatment of Head and Neck Paragangliomas"],"prefix":"10.1002","volume":"48","author":[{"given":"Christina","family":"Sauter","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Heidelberg University Hospital  Heidelberg Germany"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Augsburg University Hospital  Augsburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Erhart","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dittmar","family":"B\u00f6ckler","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Schuler","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.","family":"Plinkert","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-296X","authenticated-orcid":false,"given":"Ralph","family":"Hohenberger","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Heidelberg University Hospital  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489420931540"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.10.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(Sup01)05"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10252"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anorl.2013.05.003"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022\u2010022\u201009704\u20106"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201021\u20100359"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30226"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201007\u20100464"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13040744"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25609"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000283"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2024.01.017"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2021.08.014"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25664"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28923"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2013.08.020"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014\u20101026"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101301302"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005\u20101862"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE\u201017\u20100074"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201014\u2010523"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00772\u2010022\u201000919\u20109"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010013\u20102942\u20105"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23127"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100032\u20101314310"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.06.002"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26231"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002250"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0307311"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70084","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70084","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T06:55:40Z","timestamp":1773125740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/hed.70084"],"URL":"https:\/\/doi.org\/10.1002\/hed.70084","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"2025-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}