{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:06:13Z","timestamp":1792087573905,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent opioid use after head and neck cancer surgery is a growing concern, but data regarding incidence and risk factors remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included patients who underwent primary resection of oral cavity squamous cell carcinoma between 2016 and 2022. Preoperative opioid use was classified as na\u00efve, intermittent, or chronic using prescription drug monitoring data. Persistent use was defined as filling an opioid prescription attributed to surgery and two consecutive prescriptions between 120 and 365\u2009days postoperatively. Regression analysis identified independent predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 430 subjects, 18.8% met criteria for persistent opioid use. Chronic preoperative use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), G\u2010tube persistence at 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041), chronic pain diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036), and cancer recurrence (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021) were independent predictors. Persistent use peaked between 120 and 180\u2009days postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent opioid use is common after oral cancer resection and is strongly associated with preoperative opioid use. Early risk stratification may improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70089","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:13:46Z","timestamp":1761394426000},"page":"843-855","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Persistent Opioid Use Following Resection of Oral Cavity Squamous Cell Carcinoma: Incidence and Risk Factors"],"prefix":"10.1002","volume":"48","author":[{"given":"Cameron C.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery University of Maryland Medical Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Gandotra","sequence":"additional","affiliation":[{"name":"Department of Oral\u2010Maxillofacial Surgery University of Maryland Medical Center  Baltimore Maryland 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