{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:13:48Z","timestamp":1787948028947,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate postoperative health\u2010related quality of life (HRQoL) for pituitary adenoma patients, multidimensional assessment is important. Available data is limited on long\u2010term follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospectively, 52 nonfunctioning (NFA) and functioning (FA) pituitary adenoma patients were included. The Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES\u2010Q) was completed preoperatively and postoperatively (2\u2009weeks, 3\u2009months, 1\u2009year, 8.5\u2009years). Generalized estimating equations identified variables associated with HRQoL changes over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Psychological (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and social HRQoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) significantly improved after very long\u2010term follow\u2010up, while\u00a0physical HRQoL and EES\u2010Q scores normalized. Pre\u2010 and postoperatively, most inconveniences were reported in the social domain, with a noticeable difference between NFA and FA patients. Female gender negatively impacted physical HRQoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Endoscopic endonasal surgery has no very long\u2010term negative impact on HRQoL. Social functioning remained the most affected throughout follow\u2010up. These results highlight the importance of this multidimensional HRQoL tool to improve patient\u2010centered health care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70103","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:04:56Z","timestamp":1764324296000},"page":"1088-1096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Very Long\u2010Term Follow\u2010Up of Multidimensional Health\u2010Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-0546","authenticated-orcid":false,"given":"Gonneke E.","family":"Joustra","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"},{"name":"Graduate School of Medical Sciences University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0457-9439","authenticated-orcid":false,"given":"Nathalie F.","family":"van Rhee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-613X","authenticated-orcid":false,"given":"Marc C.","family":"den Heijer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"},{"name":"Graduate School of Medical Sciences University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-7698","authenticated-orcid":false,"given":"Astrid G. W.","family":"Korsten\u2010Meijer","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-0847","authenticated-orcid":false,"given":"Robert A.","family":"Feijen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-2260","authenticated-orcid":false,"given":"Gy\u00f6rgy B.","family":"Halmos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-5853","authenticated-orcid":false,"given":"Jos M. A.","family":"Kuijlen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9257-2791","authenticated-orcid":false,"given":"Karin M.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University Medical Center Groningen University of Groningen  Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa200"},{"issue":"5","key":"e_1_2_11_3_1","first-page":"319","article-title":"Pituitary Adenomas: An Overview","volume":"88","author":"Lake M. 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