{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:00:13Z","timestamp":1780999213697,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373439"],"award-info":[{"award-number":["82373439"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is much controversy on the extent of lymph node dissection (LND) for papillary thyroid carcinoma (PTC) patients with lymph node metastasis (LNM) according to major guidelines. This study aims to explore the optimal extent of LND and discover a personalized and accurate surgical plan for pN1 PTC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 550 patients with PTC who underwent initial surgery. For patients who were considered pN1a, LND of levels III and IV was completed. For patients who were considered LNM in levels III or IV, after taking 3\u20136 lymph nodes of level III for frozen pathological examination, if LNM was found, LND of levels II\u2013IV was performed; otherwise, only levels III and IV were dissected, For patients who were considered to have LNM in level II, LND of levels II\u2013V was performed. Statistical analysis was performed using SPSS software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>51.4% of patients with pN1a had postoperative pathologically confirmed occult LNM in levels III and IV. Among patients who underwent LND of levels II\u2013IV due to positive lymph nodes in level III, 46.1% had occult LNM in level II. For patients with LNM in level II, the incidence of occult metastasis in level V was 20%. Only one patient presented with lymph node recurrence outside of the operative field. The proportion of patients with postoperative complications increased as the scope of dissection enlarged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Combined with the distribution of LNM and the number of subregions of LNM(n) in preoperative ultrasonography, it is suggested that the range of LND in the lateral neck of pN1 PTC should be\n                      <jats:italic>n<\/jats:italic>\n                      \u2009+\u20091\/2 anatomical subregions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70116","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:15:33Z","timestamp":1769490933000},"page":"1630-1640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Trial on Optimal Extent of Lateral Neck Dissection in\n                    <scp>pN1<\/scp>\n                    Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1987-8548","authenticated-orcid":false,"given":"Shixu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-9664","authenticated-orcid":false,"given":"Huizhu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7227-1762","authenticated-orcid":false,"given":"Zehao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4422-3591","authenticated-orcid":false,"given":"Lingdun","family":"Zhuge","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9499-8806","authenticated-orcid":false,"given":"Zhaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7431-1445","authenticated-orcid":false,"given":"Wan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-9750","authenticated-orcid":false,"given":"Lijuan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1002-0745","authenticated-orcid":false,"given":"Dangui","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0686-9448","authenticated-orcid":false,"given":"Zhengjiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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