{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:58:37Z","timestamp":1787497117207,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K18835"],"award-info":[{"award-number":["24K18835"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate clinical outcomes and quality of life (QOL) following hypofractionated spot\u2010scanning proton therapy (SSPT) for head and neck malignant mucosal melanoma (HNMM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 39 patients treated with SSPT (60\u201364\u2009Gy[RBE] in 15\u201316 fractions) between 2013 and 2023. Endpoints included overall survival (OS), local control (LC), progression\u2010free survival (PFS), toxicities, and QOL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most tumors were located in the sinonasal cavity (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932). Surgery was performed in 8 patients; 19 received immune checkpoint inhibitors post\u2010SSPT. The 3\u2010year OS, LC, and PFS were 50%, 83%, and 30%, respectively. Larger tumor volumes (\u2265\u200920\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      ) were linked to worse PFS. Grade 3 mucositis occurred in 13%. Late toxicities included sinus disorder, osteonecrosis, and blindness (3%\u20135%). QOL was largely preserved, with notable declines in pain, swallowing, and mouth opening.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SSPT provides favorable LC with acceptable toxicity. Effective systemic therapies are needed to improve long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70121","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T11:21:34Z","timestamp":1764760894000},"page":"1208-1217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypofractionated Spot Scanning Proton Therapy for Head and Neck Mucosal Melanoma: A Retrospective Analysis With Quality\u2010of\u2010Life Outcome"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-7836","authenticated-orcid":false,"given":"Koichiro","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-9800","authenticated-orcid":false,"given":"Hiromitsu","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2335-3309","authenticated-orcid":false,"given":"Yusuke","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuou","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"},{"name":"Department of Radiology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Proton Therapy Technology Nagoya Proton Therapy Center, Nagoya City West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Toshito","sequence":"additional","affiliation":[{"name":"Department of Proton Therapy Physics Nagoya Proton Therapy Center, Nagoya City West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Fukano","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hiwatashi","sequence":"additional","affiliation":[{"name":"Department of Radiology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.01.019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23872"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24976"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199402000-00001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26470"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.12.028"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2614"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.110003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-162"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.10.025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-013-0489-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110180"},{"key":"e_1_2_9_14_1","unstructured":"Particle Therapy Co\u2010Operative Group Facilities in Operation 2025 https:\/\/ptcog.site\/index.php\/facilities\u2010in\u2010operation\u2010public."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.05.011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/6\/013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.01.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13246-016-0456-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.14338\/IJPT-D-20-00043.1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12231"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.057"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.139"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.08.002"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.09.007"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrw117"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217236.06585.a9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6006"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrz036"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12103022"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30700-9"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709937"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.08.034"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70121","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70121","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:31:51Z","timestamp":1775565111000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/hed.70121"],"URL":"https:\/\/doi.org\/10.1002\/hed.70121","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,3]]},"assertion":[{"value":"2025-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}