{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:41:34Z","timestamp":1792086094826,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011892","name":"Kaohsiung Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG8N0151"],"award-info":[{"award-number":["CMRPG8N0151"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of the worst pattern of invasion\u20105 (WPOI\u20105) for patients with pathologically early\u2010stage and low\u2010risk oral tongue squamous cell carcinoma (OTSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 224 patients treated between 2005 and 2016 were analyzed. WPOI\u20105 was defined as tumor satellites \u2265\u20091\u2009mm from the main tumor or nearest satellite. Its prognostic impact on cancer\u2010specific survival (CSS) and locoregional recurrence\u2010free survival (LRRFS) was assessed, and a WPOI\u20105\u2010based nomogram was developed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with WPOI\u20105 had significantly worse 5\u2010year CSS and LRRFS (both\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In Cox analysis, WPOI\u20105 independently predicted poorer CSS (HR 6.908,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and LRRFS (HR 14.910,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Adding WPOI\u20105 improved the nomogram's 5\u2010year LRRFS AUC from 0.789 to 0.842.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>WPOI\u20105 is an adverse prognostic factor in pathologically early\u2010stage, low\u2010risk OTSCC and may justify trials of adjuvant therapy in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70135","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T09:25:03Z","timestamp":1765790703000},"page":"1287-1293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Prognostic Value of Worst Pattern of Invasion\u20105 on Low\u2010Risk and Early\u2010Stage Oral Tongue Cancer"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-1579","authenticated-orcid":false,"given":"Ming\u2010Hsien","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Chi","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Pathology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ching","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-8638","authenticated-orcid":false,"given":"Yu\u2010Tsai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University  Taoyuan Taiwan"},{"name":"School of Medicine, Chang Gung University College of Medicine  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-7160","authenticated-orcid":false,"given":"Hui","family":"Lu","sequence":"additional","affiliation":[{"name":"Doctoral Program of Clinical and Experimental Medicine National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yen","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine  Kaohsiung Taiwan"},{"name":"Doctoral Program of Clinical and Experimental Medicine National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Min","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Medicine, Chang Gung University College of Medicine  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine, National Sun Yat\u2010Sen University  Kaohsiung Taiwan"},{"name":"Department of Radiation Oncology Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine  Kaohsiung 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