{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:43Z","timestamp":1786977943716,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011851","name":"Kom op tegen Kanker","doi-asserted-by":"publisher","award":["KotK_KUL\/2019\/11813\/1"],"award-info":[{"award-number":["KotK_KUL\/2019\/11813\/1"]}],"id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The HIT\u2010CRAD trial (ISRCTN57028065) is the first to combine home\u2010based non\u2010invasive brain stimulation with high\u2010volume strength and skill training over 8\u2009weeks in patients with chronic radiation\u2010associated dysphagia (CRAD) following primary (chemo)radiotherapy for head and neck cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010four patients were randomized into three groups. Group 1 performed 8\u2009weeks of strength training. Groups 2 and 3 combined 4\u2009weeks of strength training with 4\u2009weeks of skill training. Group 3 received high\u2010definition transcranial direct current stimulation (HD\u2010tDCS) during training. Group 2 received sham HD\u2010tDCS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall adherence and exercise adherence remained above 75% across all groups. Home\u2010based HD\u2010tDCS proved safe and feasible, with mild to moderate side effects (tingling, itching, or burning). Median exercise performance levels for strength training exercises ranged from 94% to 100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study confirms the feasibility of high\u2010volume strength and skill training with HD\u2010tDCS in patients with C\u2010RAD. Proactive adherence\u2010supporting factors facilitate high adherence in this population. Both real and sham HD\u2010tDCS proved safe, feasible, and well tolerated.\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      International Standard Randomized Controlled Trials Number (ISRCTN) registry ID ISRCTN57028065\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70136","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:55:14Z","timestamp":1766220914000},"page":"1340-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Feasibility and Adherence to Home\u2010Based Intensive Treatment Programs for Chronic Radiation\u2010Associated Dysphagia in Head and Neck Cancer Survivors\u2014The HIT\u2010CRAD 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