{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T13:06:46Z","timestamp":1775567206508,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Microvascular free tissue transfer (MFTT) is the standard in the reconstruction of major head and neck defects, but involves extended hospital stays and an increased risk of post\u2010operative delirium (POD). What risk factors increase the risk of POD in patients undergoing MFTT, and subsequent complications?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of 168 patients undergoing MFTT following ablation of oral cavity or oropharyngeal cancer. Patient demographic data, operative data, post\u2010operative ventilatory support needs, post\u2010operative complications, and post\u2010operative sedation and analgesic needs were collected, and the association with POD was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      POD was significantly associated with opioid (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0018) and sedation requirements (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), postoperative return to the OR (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and medical complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033). There was no association with the rate of MFTT failure (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In MFTT patients, opioid and sedative administration are potentially modifiable factors that may be able to reduce POD incidence and optimize the postoperative course of patients undergoing MFTT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70137","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:37:54Z","timestamp":1765611474000},"page":"1279-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rates of\n                    <scp>ICU<\/scp>\n                    Delirium After Microvascular Free Tissue Transfer Reconstruction of the Oral Cavity and Oropharynx"],"prefix":"10.1002","volume":"48","author":[{"given":"William","family":"Nesmith","sequence":"first","affiliation":[{"name":"University of California, San Francisco School of Medicine  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7332-6998","authenticated-orcid":false,"given":"Shayan","family":"Fakurnejad","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9360-3235","authenticated-orcid":false,"given":"Danielle","family":"Gillard","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8180-4542","authenticated-orcid":false,"given":"Katherine","family":"Wai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Jue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Likhterov","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"George","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-3726","authenticated-orcid":false,"given":"Ivan","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-6147","authenticated-orcid":false,"given":"Patrick","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Head and Neck Surgical Oncology University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of Facial Plastics and Reconstructive Surgery University of California, San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Seth","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery, Division of 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