{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T13:06:49Z","timestamp":1775567209187,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Brain metastases (BM) of differentiated thyroid carcinoma (DTC) are associated with unfavorable prognosis. This study evaluated BM management strategies and patients' outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of patients diagnosed with DTC and BM at Tel Aviv Sourasky and Rabin Medical Centers between 1985 and 2024. Clinical features, histopathology, treatments, and survival data were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients were identified: 11 (55%) had papillary thyroid carcinoma, 8 (40%) had follicular carcinoma and 1 had Hurtle cell carcinoma. BM treatments included neurosurgical resection (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099), stereotactic radiosurgery (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914), and whole\u2010brain radiotherapy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Median survival following BM diagnosis was 16.2\u2009months. Patients who did not undergo surgical resection had significantly shorter survival than those whose BM were resected (13 vs. 80\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Survival was also worse among patients receiving systemic therapy at the time BM developed (8.9 vs. 80\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Unresected BM of DTC and those arising during systemic therapy portend high mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70139","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:04:52Z","timestamp":1766156692000},"page":"1332-1339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Metastases From Differentiated Thyroid Cancer in the Era of Targeted Therapies: A Multi\u2010Center Retrospective Cohort"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2088","authenticated-orcid":false,"given":"Liyona","family":"Kampel","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck and Maxillofacial Surgery Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"The Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Edalati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck and Maxillofacial Surgery Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"The Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Yosefof","sequence":"additional","affiliation":[{"name":"The Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv 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Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidal","family":"Muhanna","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck and Maxillofacial Surgery Tel Aviv Sourasky Medical Center  Tel Aviv Israel"},{"name":"The Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Shoffel\u2010Havakuk","sequence":"additional","affiliation":[{"name":"The Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Otolaryngology Head and Neck Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Robenshtok","sequence":"additional","affiliation":[{"name":"The Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Rabin Medical Center Institute of Endocrinology, Diabetes and Metabolism  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