{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:31:17Z","timestamp":1780497077928,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The gingiva and floor of the mouth are distinct subsites, and oral squamous cell carcinoma (OSCC) originating in these locations warrants further indepth understanding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study enrolled patients with OSCC from 2000 to 2020, and analyzed the clinicopathological characteristics. Kaplan\u2013Meier analysis compared overall survival (OS) and recurrence\u2010free survival (RFS). Univariate analysis and multivariate Cox proportional hazards model examined the risk factors on survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 885 OSCC patients were included, with the most common tumor subsites: oral tongue (41.9%), gingiva (31.8%), and floor of mouth (16.0%). Gingival and floor of mouth showed a higher proportion of advanced stage (65.8%, 66.9%) and significantly poorer OS (3\u2010year: 63.0%, 57.0%; 5\u2010year: 49.8%, 37.3%) and RFS (3\u2010year: 59.1%, 61.3%; 5\u2010year: 55.5%, 57.0%). Neoadjuvant chemotherapy was associated with significantly reduced mortality in gingival cancer (HR\u2009=\u20090.598), while tobacco exposure (HR\u2009=\u20091.952) was associated with a significant increase in mortality in floor of mouth cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gingival cancer and floor of mouth cancer have a worse prognosis, and thus require greater attention throughout the entire management process.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70145","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:48:06Z","timestamp":1766400486000},"page":"1351-1360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Greater Attention to Gingival Cancer and Floor of Mouth Cancer: Based on a Retrospective Analysis of Oral Cancer Across Different Subsites"],"prefix":"10.1002","volume":"48","author":[{"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-0293","authenticated-orcid":false,"given":"Yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-7553","authenticated-orcid":false,"given":"Xinhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoshi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansheng","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology Tianjin Medical University Cancer Institute &amp; Hospital  Tianjin China"},{"name":"Key Laboratory of Basic and Translational Medicine on Head &amp; Neck Cancer  Tianjin China"},{"name":"National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003140"},{"key":"e_1_2_11_3_1","first-page":"178","article-title":"The Prevalence of Squamous Cell Carcinoma in Different Sites of Oral Cavity at Our Rural Health Care Centre in Loni, Maharashtra\u2014A Retrospective 10\u2010Year Study","volume":"21","author":"Tandon P.","year":"2017","journal-title":"Contemporary Oncology (Poznan, Poland)"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2423-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-05764-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0b013e3181572caa"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2024.102046"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.315105062"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.613945"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104551"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27490"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106684"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15369"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.10.019"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002408"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30107"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05400-y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2020.1750031"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25579"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01192-6"},{"key":"e_1_2_11_21_1","first-page":"955","article-title":"The Prognostic Implications of Bone Invasion in Gingival Squamous Cell Carcinoma","volume":"38","author":"Yoshida S.","year":"2018","journal-title":"Anticancer Research"},{"key":"e_1_2_11_22_1","first-page":"335","article-title":"Gingival Squamous Cell Carcinoma: A Clinical Case and Differential Diagnosis","volume":"6","author":"Chimenos K\u00fcstner E.","year":"2001","journal-title":"Medicina Oral"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050408"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05078-9"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/189303"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6915a1"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14130947"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3873"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32892-y"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14164044"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2011.07.002"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.07.015"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5075"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106633"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.123627"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt555"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.4170"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3475"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2023.155071"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70145","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70145","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:10:00Z","timestamp":1779941400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/hed.70145"],"URL":"https:\/\/doi.org\/10.1002\/hed.70145","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]},"assertion":[{"value":"2025-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}