{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:00:24Z","timestamp":1780999224582,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Squamous cell carcinoma (SCC) of the oral vestibule is associated with significant surgical challenges, often requiring extensive resections with functional and cosmetic sequelae. Interventional radiotherapy (IRT, brachytherapy) may provide a function\u2010preserving alternative.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed clinical data from 12 patients with primary oral vestibule SCC treated between February 2022 and March 2025. Eleven underwent high\u2010dose\u2010rate IRT (HDR\u2010IRT) with curative intent after multidisciplinary tumor board evaluation. Clinical outcomes, toxicity, and functional preservation were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 11 patients treated with HDR\u2010IRT, ten achieved a complete response. At a mean follow\u2010up of 20\u2009months, nine were alive and disease\u2010free. Two\u2010year disease\u2010specific survival and overall survival were 86% and 78%, respectively. Acute toxicity was limited to grade II mucositis, and long\u2010term sequelae were minimal, with only mild skin dyschromia. No patient developed trismus or Stensen's duct\u00a0dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Exclusive HDR\u2010IRT appears to be a safe, effective, and organ\u2010preserving therapeutic option for selected oral vestibule SCCs; however, further studies in larger cohorts are needed to validate our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70150","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:49:03Z","timestamp":1767703743000},"page":"1491-1498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interventional Radiotherapy (Brachytherapy) for the Treatment of the Primary Lesion in Squamous Cell Carcinomas of the Oral Vestibule"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4952-2729","authenticated-orcid":false,"given":"Andrea","family":"Tondo","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliera Universitaria  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7174-8126","authenticated-orcid":false,"given":"Antonella","family":"Loperfido","sequence":"additional","affiliation":[{"name":"Otolaryngology Unit, San Camillo Forlanini Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-0020","authenticated-orcid":false,"given":"Alessia","family":"Re","sequence":"additional","affiliation":[{"name":"UOC Radioterapia Oncologica, Mater Olbia Hospital  Olbia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-1867","authenticated-orcid":false,"given":"Claudia","family":"Crescio","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliera Universitaria  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9945-0658","authenticated-orcid":false,"given":"Pierangela","family":"Tramaloni","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliera Universitaria  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-6181","authenticated-orcid":false,"given":"Fabrizio","family":"Sanna","sequence":"additional","affiliation":[{"name":"Institute of Radiological Sciences, University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-1810","authenticated-orcid":false,"given":"Bruno","family":"Fionda","sequence":"additional","affiliation":[{"name":"UOC Degenze di Radioterapia Oncologica, Dipartimento di Diagnostica Per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-0982","authenticated-orcid":false,"given":"Luca","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"UOC Degenze di Radioterapia Oncologica, Dipartimento di Diagnostica Per Immagini e Radioterapia Oncologica, Fondazione Policlinico Universitario A. Gemelli, IRCCS  Roma Italy"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1830-3731","authenticated-orcid":false,"given":"Davide","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliera Universitaria  Sassari Italy"},{"name":"Department of Medicine Surgery and Pharmacy, University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-0413","authenticated-orcid":false,"given":"Gian Carlo","family":"Mattiucci","sequence":"additional","affiliation":[{"name":"UOC Radioterapia Oncologica, Mater Olbia Hospital  Olbia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-2772","authenticated-orcid":false,"given":"Francesco","family":"Bussu","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Azienda Ospedaliera Universitaria  Sassari Italy"},{"name":"Department of Medicine Surgery and Pharmacy, University of Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"International Classification of Diseases for Oncology: ICD\u2010O","author":"World Health Organization","year":"2013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2025.0007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110533"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5195\/jmla.2018.319"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2025.2449829"},{"key":"e_1_2_9_7_1","volume-title":"TNM Classification of Malignant Tumours","year":"2025"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.20517\/2574\u20101225.2024.41"},{"key":"e_1_2_9_9_1","first-page":"3","volume-title":"In the GEC\u2010ESTRO Handbook of Brachytherapy. 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