{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:27:09Z","timestamp":1785814029384,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Two\u2010month outcomes of advanced pneumatic compression device (APCD) and usual care (UC) in Head and Neck Cancer survivors with previously untreated lymphedema were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants in this multisite, randomized clinical trial were randomized to APCD or UC. The primary endpoint was severity of lymphedema symptoms. Secondary endpoints were anatomical lymphedema changes, biopsychosocial outcomes, and barriers to care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred thirty\u2010six participants were enrolled (119 APCD, 117 UC). Analysis was intention\u2010to\u2010treat. Lymphedema\u2010associated symptom burden measured using the VHNSS and LSIDS was improved to a similar degree in both groups. APCD demonstrated a statistically significant improvement in external soft tissue swelling assessed by digital photography. No difference in CT imaging measures of lymphedema was noted. UC participants experienced barriers to care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>APCD is an effective treatment for lymphedema in HNCS. The APCD addresses clinically significant barriers to therapist guided treatment. A hybrid approach may be complementary and optimize patient outcomes.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      NCT04797390.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70155","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:36:50Z","timestamp":1769168210000},"page":"1077-1087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Short\u2010Term Outcomes of Advanced Pneumatic Compression Device Versus Usual Care Therapy for Head and Neck Cancer\u2010Related Lymphedema: A Multi\u2010Site Randomized Clinical Trial"],"prefix":"10.1002","volume":"48","author":[{"given":"Barbara A.","family":"Murphy","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Computational Biology University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina M.","family":"Kline\u2010Quiroz","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Advanced Head &amp; Neck Rehabilitation Center of Texas  Fort Worth Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar W.","family":"Sukari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Karmanos Cancer Institute  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir K.","family":"Bhayani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Montefiore Medical Center  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Quon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins Medical Center  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Willey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Alabama Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal E.","family":"Dunlap","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Louisville Research Foundation Inc. University of Louisville  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Radiation Oncology Richmond University Medical Center  Staten Island New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Aulino","sequence":"additional","affiliation":[{"name":"Department of Radiology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila H.","family":"Ridner","sequence":"additional","affiliation":[{"name":"School of Nursing Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"American Cancer Society \u201cCancer Facts & Figures\u00a02024 \u201daccessed July 15 2024 https:\/\/www.cancer.org\/content\/dam\/cancer\u2010org\/research\/cancer\u2010facts\u2010and\u2010statistics\/annual\u2010cancer\u2010facts\u2010and\u2010figures\/2024\/2024\u2010cancer\u2010facts\u2010and\u2010figures\u2010acs.pdf."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2023.04.017"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2023.102383"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2016.0001"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1188\/11.ONF.E1\u2010E10"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-222695"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23084"},{"key":"e_1_2_12_9_1","first-page":"35","volume-title":"Dysphagia in Head and Neck Cancer Patients Treated With Radiation: Assessment, Sequelae, and Rehabilitation","author":"Murphy B. 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