{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:00:18Z","timestamp":1780999218715,"version":"3.54.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Human papillomavirus\u2010related (HPV+) sinonasal squamous cell carcinoma (SNSCC) is associated with improved overall survival (OS) compared to similarly staged HPV\u2010negative SNSCC. However, data on treatment\u2010specific outcomes remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the National Cancer Database (NCDB) for all SNSCC cases diagnosed between 2010 and 2017 with available HPV testing data. Prognostically significant variables were identified via multivariable Cox regression. Propensity score\u2010matched cohorts were then created, matching HPV\u2010positive and HPV\u2010negative patients exactly by treatment modality and other significant prognostic factors. The association between HPV status and 5\u2010year OS was assessed across treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1697 HPV\u2010tested SNSCC cases were identified; 551 (32.5%) were HPV+. Multivariable Cox regression showed that HPV status, age, comorbidity score, tumor size, lymphovascular invasion, stage, and surgical margin status were significantly associated with outcomes. Within the propensity score\u2010matched cohort, HPV positivity was significantly associated with improved OS among patients treated with chemoradiation (HR\u2009=\u20090.55; 95% CI\u2009=\u20090.35\u20130.87,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). No survival benefit was observed in patients treated with surgery alone (HR\u2009=\u20090.85; 95% CI\u2009=\u20090.35\u20132.04,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.71), surgery with radiation (HR\u2009=\u20091.38; 95% CI\u2009=\u20090.64\u20133.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.41), radiation alone (HR\u2009=\u20090.40; 95% CI\u2009=\u20090.11\u20131.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16), or in the combined group of these three treatment strategies (HR\u2009=\u20090.97; 95% CI\u2009=\u20090.57\u20131.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.90).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that HPV+ SNSCC may be particularly sensitive to chemoradiation. Routine HPV testing may be warranted to investigate if tailored treatment approaches focusing on chemoradiation may benefit patients with HPV+ SNSCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70156","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:20:24Z","timestamp":1767867624000},"page":"1510-1518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved Survival of\n                    <scp>HPV<\/scp>\n                    \u2010Related Sinonasal Squamous Cell Carcinoma With Chemoradiation Treatment"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-7756","authenticated-orcid":false,"given":"Jamie R.","family":"Oliver","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2023-3170","authenticated-orcid":false,"given":"Naomi C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Alapati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6000-5413","authenticated-orcid":false,"given":"Easton","family":"Attwood","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameen","family":"Amanian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-6453","authenticated-orcid":false,"given":"Andr\u00e9s M.","family":"Bur","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. David","family":"Beahm","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Kansas School of Medicine  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112835"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19920115)69:2<353::aid\u2010cncr2820690213>3.0.co;2\u2010j"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182698673"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34690"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.97"},{"key":"e_1_2_10_7_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology","author":"NCCN","year":"2025"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32679"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.1311"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26477"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081874"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010015\u20101812\u2010x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26134"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001410"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2024.104243"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0307658"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.02.017"},{"key":"e_1_2_10_18_1","unstructured":"National Cancer Database 2025 https:\/\/www.facs.org\/quality\u2010programs\/cancer\u2010programs\/national\u2010cancer\u2010database\/about\/."},{"key":"e_1_2_10_19_1","volume-title":"International Classification of Diseases for Oncology (ICD\u2010O), 1st Revision","author":"World Health Organization","year":"2013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00684"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.468"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23423"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21996"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33611"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599815592157"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201058502\u20109"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/696028"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153677"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001566"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.155"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301213280302"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12345"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.45818"},{"key":"e_1_2_10_35_1","unstructured":"National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology: Head and Neck Cancers. 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