{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:00:24Z","timestamp":1780999224560,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme United Kingdom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R25DC021243"],"award-info":[{"award-number":["R25DC021243"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Sinonasal carcinomas are rare but aggressive malignancies. A subset is associated with high\u2010risk HPV, but risk factors for HPV\u2010associated sinonasal carcinoma (HPV\u2010SNC) and HPV\u2010independent disease remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate behavioral and clinical risk factors, including sexual history and substance use, and HPV antibody seropositivity in patients with HPV\u2010SNC and HPV\u2010independent SNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>\n                      This multi\u2010institutional case\u2013case\u2013control study was conducted from 2021 to 2024 at two NCI\u2010designated cancer centers. Fifty\u2010two patients with sinonasal carcinoma were enrolled; 37 completed a survey of demographic, clinical, and behavioral factors (24 HPV\u2010SNC, 13 HPV\u2010independent SNC) and serology was obtained for 36 (24 HPV\u2010SNC, 12 HPV\u2010independent SNC). Control noncancer otolaryngology patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009148) from a recent prior study were matched 4:1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Exposure<\/jats:title>\n                    <jats:p>Self\u2010reported history of sexual behaviors, substance use, and medical history via electronic survey; serum testing for antibodies to low\u2010 and high\u2010risk HPV E6, E7, E1, E2, and L1 oncoproteins using a multiplex bead\u2010based assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome and Measure<\/jats:title>\n                    <jats:p>Odds of HPV\u2010SNC or HPV\u2010independent SNC diagnosis in relation to risk factors; differences in HPV seropositivity between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 37 cancer patients who completed the survey, a history of tonsillectomy was significantly associated with reduced odds of HPV\u2010SNC (OR 0.28, CI 0.09\u20130.86). No other factors explored (sexual behavior, substance use, or other clinical factors) were associated with HPV\u2010associated SNC and HPV\u2010independent SNC. Seroprevalence of anti\u2010HPV16 E6 was significantly higher among HPV\u2010associated SNC cases than either controls or HPV\u2010independent SNC (45.8% vs. 0% and 13.1%), HPV\u201016 E6 (18.2% vs. 0% and 4.0%), and HPV\u201016 early proteins (16.7% vs. 0% and 0%) than HPV\u2010independent SNC patients or controls, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Relevance<\/jats:title>\n                    <jats:p>HPV\u2010SNC exhibits distinct serologic features without clear behavioral risk factors. The protective association of tonsillectomy suggests lymphoid tissue may play a role in HPV\u2010associated sinonasal oncogenesis. In contrast, the absence of identifiable risk factors for HPV\u2010independent SNC highlights the need for further etiologic studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70171","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:45:41Z","timestamp":1769687141000},"page":"1641-1646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Behavioral Risk Factors and Seroprevalence for Human Papillomavirus in Sinonasal Carcinoma: A Multi\u2010Institutional Case\u2013Control Study"],"prefix":"10.1002","volume":"48","author":[{"given":"Ved","family":"Tanavde","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-1009","authenticated-orcid":false,"given":"Anuj","family":"Tharakan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gypsyamber","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Abi","family":"Hachem","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina J.","family":"Windon","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Alkahtani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"So","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery and Communication Sciences Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvir","family":"Queraishi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubair","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Michels","sequence":"additional","affiliation":[{"name":"Division of Infections and Cancer Epidemiology 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