{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:58:57Z","timestamp":1791968337880,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cutaneous adnexal carcinomas are a very rare group of cancers arising from appendageal structures of the skin. More than half occur in the head and neck region. No standard treatments exist for metastatic disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 48\u2010year\u2010old postmenopausal female presented with an enlarging scalp lesion. Biopsy showed adenocarcinoma that was positive for estrogen and progesterone receptors. She underwent wide local excision with adjuvant radiation. Unfortunately, she presented with metastatic disease 1.5\u2009years later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Given the tumor's hormone receptor profile, she was started on an aromatase inhibitor (AI) and a cyclin\u2010dependent kinase 4\/6 (CDK4\/6) inhibitor with a durable partial response for 2.5\u2009years at the time of this report. She continues to work full\u2010time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first case study describing the success of hormonal therapy combined with a CDK4\/6 inhibitor\u00a0for a rare head and neck cancer. Cutaneous adenocarcinomas in the head and neck region should have routine immunohistochemical assessment of hormone receptors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70178","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:09:26Z","timestamp":1769515766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metastatic Cutaneous Adnexal Carcinoma of the Head and Neck With Durable Response to an Aromatase Inhibitor Combined With a Cyclin\u2010Dependent Kinase 4\/6 Inhibitor"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-619X","authenticated-orcid":false,"given":"Nilesh","family":"Kapoor","sequence":"first","affiliation":[{"name":"Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-8054","authenticated-orcid":false,"given":"Manasa","family":"Narasimman","sequence":"additional","affiliation":[{"name":"Division of Digestive and Liver Diseases, Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Vandergriff","sequence":"additional","affiliation":[{"name":"Department of Dermatology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Classification of Skin Tumours: WHO Classification of Tumours, Volume 11","author":"Elder D. 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