{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:00:32Z","timestamp":1780999232960,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate oncological outcomes and their predictors following salvage oropharyngectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective study included patients who underwent a salvage oropharyngectomy in an irradiated neck for recurrent or metachronous oropharyngeal squamous cell carcinoma (OPSCC) between 2014 and 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010four patients were included. Five\u2010year overall survival (OS), disease\u2010specific survival (DSS), and local recurrence\u2010free survival (LRFS) were 31.7%, 58.5%, and 55.2%, respectively. In multivariable analysis, pN+ status (HR 2.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031), pT status\u2009\u2265\u20093 (HR 2.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020), and age (HR 1.05;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) were associated with OS. DSS was associated with pT status\u2009\u2265\u20093 (HR 5.24;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), metachronous (vs. recurrent) OPSCC (HR 0.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), and cN+ status (HR 2.31;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.053). LRFS was associated with metachronous OPSCC (HR 0.30;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and pT status\u2009\u2265\u20093 (HR 3.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This last\u2010resort procedure is associated with poor survival outcomes. In this series, patients with p16\u2010positive OPSCC did not fare better than their p16\u2010negative counterparts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70182","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:13:50Z","timestamp":1769764430000},"page":"1668-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oncological Outcomes of Salvage Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"48","author":[{"given":"Jade","family":"Saykaly","sequence":"first","affiliation":[{"name":"Department of Surgery, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; Throat Surgery, Toulouse University Hospital\u2014Larrey Hospital Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Vergez","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; Throat Surgery, Toulouse University Hospital\u2014Larrey Hospital Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Dupret\u2010Bories","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; Throat Surgery, Toulouse University Hospital\u2014Larrey Hospital Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouchka","family":"Modesto","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Vairel","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; Throat Surgery, Toulouse University Hospital\u2014Larrey Hospital Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Sarini","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; Throat Surgery, Toulouse University Hospital\u2014Larrey Hospital Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Siegfried","sequence":"additional","affiliation":[{"name":"Department of Pathology University Cancer Institute of Toulouse\u2014Oncopole, Universit\u00e9s de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cavillon","sequence":"additional","affiliation":[{"name":"Biostatistics &amp; Health Data Science Unit, Oncopole Claudius Regaud University Cancer Institute of Toulouse\u2014Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-2846","authenticated-orcid":false,"given":"Emilien","family":"Chabrillac","sequence":"additional","affiliation":[{"name":"Department of Surgery, University Cancer Institute of Toulouse\u2014Oncopole, Oncopole Claudius Regaud Universit\u00e9s de Toulouse  Toulouse France"},{"name":"Department of Ear, Nose &amp; 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