{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:57:57Z","timestamp":1787612277757,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ultrasound\u2010guided fine\u2010needle aspiration cytology (US\u2010FNAC) is commonly used in the diagnostic work\u2010up of head and neck cancer, but its ability to detect occult lymph node metastases in early\u2010stage oral squamous cell carcinoma (OSCC) with a clinically negative neck remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed in 578 patients with early\u2010stage OSCC (cT1\u20103N0) who underwent US\u2010FNAC prior to surgery. Histopathology, sentinel lymph node biopsy, and follow\u2010up were used as reference standards.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Occult nodal metastases were found in 179 patients (31.0%). US\u2010FNAC showed low sensitivity (15.9%) and a negative predictive value of 72.9%, resulting in 149 false\u2010negative cases (25.8%). Specificity (99.5%) and positive predictive value (90.3%) were high, with only 2 false\u2010positive results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with early\u2010stage oral cavity squamous cell carcinoma and a clinically negative neck, US\u2010FNAC demonstrates high specificity but limited sensitivity and negative predictive value. These findings indicate that US\u2010FNAC alone is insufficient to exclude occult nodal metastases and should be regarded as an adjunctive diagnostic tool rather than a stand\u2010alone nodal staging strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70183","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:52:51Z","timestamp":1769514771000},"page":"1620-1629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Limited Sensitivity of Ultrasound\u2010Guided Fine\u2010Needle Aspiration Cytology for Occult Nodal Metastases in Early\u2010Stage Oral Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"48","author":[{"given":"Dominique N. V.","family":"Donders","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosmarijn S.","family":"Tellman","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy M.","family":"Schouten","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Dankbaar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Pameijer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben E.","family":"Breimer","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-5814","authenticated-orcid":false,"given":"Remco","family":"de Bree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-9483","authenticated-orcid":false,"given":"Bart","family":"de Keizer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024327"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0128-5"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23632"},{"issue":"1","key":"e_1_2_14_5_1","first-page":"E1033","article-title":"Staging of Early Lymph Node Metastases With the Sentinel Lymph Node Technique and Predictive Factors in T1\/T2 Oral Cavity Cancer: A Retrospective Single\u2010Center Study","volume":"38","author":"Pedersen N. 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