{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:12:24Z","timestamp":1784563944858,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Beyond follicular\u2010derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective case series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight patients with aggressive thyroid tumors presented with clinical and radiographic features concerning for anaplastic thyroid cancer (ATC). Three patients presumed to be diagnosed with Adamantinoma\u2010like Ewing sarcoma (ALES), each harboring an\n                      <jats:italic>EWSR1\u2010FLI1<\/jats:italic>\n                      rearrangement. One patient with an enlarging neck mass was found to have osteoid\u2010producing osteosarcoma. Another patient with a bulky neck mass and metastases demonstrated neolumen and ERG\/CD31 positivity, confirming thyroid angiosarcoma. A separate patient was diagnosed with a high\u2010grade sarcoma harboring a\n                      <jats:italic>PRMT8\u2010NTRK<\/jats:italic>\n                      fusion, representing the first reported case. Two patients had mucoepidermoid carcinoma (MEC) variants\u2014one classic MEC and one sclerosing MEC with eosinophilia (SMECE).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multiple rare thyroid malignancies may present indistinguishably from ATC, emphasizing the need for meticulous histopathologic and molecular evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70201","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:21:27Z","timestamp":1773642087000},"page":"2180-2189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6727-4378","authenticated-orcid":false,"given":"David Z.","family":"Allen","sequence":"first","affiliation":[{"name":"The Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Texas Health Science Center at Houston  Houston Texas USA"},{"name":"Department of Head and Neck Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Mohsen","family":"Hosseini","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Division of Pathology\/Lab Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7918-9739","authenticated-orcid":false,"given":"Mark","family":"Zafereo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0736-7473","authenticated-orcid":false,"given":"Miriam","family":"Lango","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Gardner","family":"Grubbs","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Division of Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreyaskumar R.","family":"Patel","sequence":"additional","affiliation":[{"name":"The Department of Sarcoma Medical Oncology, Division of Cancer Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Ravi","sequence":"additional","affiliation":[{"name":"The Department of Sarcoma Medical Oncology, Division of Cancer Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naifa Lamki","family":"Busaidy","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-3832","authenticated-orcid":false,"given":"Rui Jennifer","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Division of Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Williams","sequence":"additional","affiliation":[{"name":"The Department of Pathology, Division of Pathology\/Lab Medicine The University of Texas MD Anderson Cancer Center  Houston Texas 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