{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:25:42Z","timestamp":1783164342727,"version":"3.54.6"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head & Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Kaposi's sarcoma (KS) is a vascular neoplasm associated with human herpesvirus\u20108 infection and is common in HIV\u2010infected individuals. Immune reconstitution inflammatory syndrome (IRIS) following antiretroviral therapy (ART) may paradoxically unmask or exacerbate KS. Laryngeal involvement is extremely rare and carries a high risk of bleeding, posing diagnostic and therapeutic challenges.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We report a 34\u2010year\u2010old HIV\u2010positive man who developed rapidly progressive laryngeal KS shortly after initiating ART, consistent with IRIS\u2010associated KS. The patient presented with severe supraglottic obstruction requiring tracheostomy. Preoperative selective transarterial embolization of the feeding superior laryngeal artery was performed prior to transoral tumor resection. This study was conducted under the ethical oversight of the National Hospital Organization Kyushu Medical Center (Approval No. 22C005), and individual informed consent was waived due to retrospective data anonymization.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Preoperative embolization resulted in marked tumor shrinkage, enabling complete and nearly bloodless excision. Histopathological and immunohistochemical analysis confirmed KS. The patient experienced no recurrence during follow\u2010up.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Preoperative transarterial embolization is a feasible and effective adjunct in managing laryngeal KS associated with IRIS, particularly in cases with airway compromise and high bleeding risk. This strategy may facilitate safe surgical intervention in highly vascular tumors.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hed.70202","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:59:33Z","timestamp":1771052373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngeal Kaposi's Sarcoma Triggered by Immune Reconstitution Inflammatory Syndrome Successfully Resected With Preoperative Arterial Embolization: A Case Report"],"prefix":"10.1002","volume":"48","author":[{"given":"Ryosuke","family":"Kuga","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3502-817X","authenticated-orcid":false,"given":"Hideoki","family":"Uryu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Neuroendovascular Therapy National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Takahama","sequence":"additional","affiliation":[{"name":"AIDS\/HIV Clinical Center, National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torahiko","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery National Hospital Organization Kyushu Medical Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.597"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis308"},{"issue":"12","key":"e_1_2_11_4_1","first-page":"4044","article-title":"Reactivation and Persistence of Human Herpesvirus\u20108 Infection in B Cells and Monocytes by Th1 Cytokines Increased in Kaposi's Sarcoma","volume":"93","author":"Monini P.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221105059"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.47162\/RJME.64.4.13"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328360a5a1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5813"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"1","article-title":"Surveillance for AIDS\u2010Defining Opportunistic Illnesses, 1992\u20101997","volume":"48","author":"Jones J. L.","year":"1999","journal-title":"MMWR. CDC Surveillance Summaries"},{"issue":"12","key":"e_1_2_11_10_1","article-title":"A Case of Non\u2010Cutaneous Kaposi Sarcoma","volume":"14","author":"Osei N.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100135698"},{"issue":"11","key":"e_1_2_11_12_1","article-title":"Transoral Robotic Surgery and Transarterial Embolization to Treat Adult Laryngeal Hemangioma","volume":"103","author":"Hung S. Y.","year":"2023","journal-title":"Ear, Nose, and Throat Journal"},{"key":"e_1_2_11_13_1","article-title":"Maxillary Sinus Kaposi Sarcoma: Case Report in an HIV\u2010Negative Patient With Thymoma","volume":"2017","author":"Ara\u00fajo B. C.","year":"2017","journal-title":"Case Reports in Otolaryngology"}],"container-title":["Head & Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:14:21Z","timestamp":1783163661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,13]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/hed.70202"],"URL":"https:\/\/doi.org\/10.1002\/hed.70202","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,13]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}