{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:15:00Z","timestamp":1783167300162,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301026"],"award-info":[{"award-number":["82301026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to systematically analyze the clinical characteristics, diagnostic controversies, and treatment outcomes of branchiogenic carcinoma (BC) to validate its status as a distinct pathological entity and evaluate the role of molecular biology in distinguishing primary carcinoma from metastatic lesions, thereby optimizing evidence\u2010based diagnostic and therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted, screening PubMed databases (1919\u20132025) for BC cases adhering to Martin\u2010Huber, Wolff, and Khafif diagnostic criteria. Inclusion criteria: (1) Tumor location: Anatomically confined to branchial cysts\/sinuses. (2) Pathology: Histopathological evidence of gradual transition from normal squamous epithelium to invasive carcinoma. (3) Primary exclusion: No detectable primary malignancy after comprehensive evaluation. (4) Occult tumor assessment: No occult primaries identified during follow\u2010up. Exclusion criteria: (1) Nonprimary BC (e.g., metastatic SCC). (2) Ambiguous diagnoses (nonconforming histology or criteria). Thirty\u2010three cases met inclusion criteria (33 for treatment analysis; 30 with full follow\u2010up). Demographic, clinicopathological, and treatment data were collected. Survival rates and risk factors were analyzed using Kaplan\u2013Meier methods and Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BC predominantly affected males (2.2:1 male\u2010to\u2010female ratio), with a peak incidence at 50\u201360\u2009years. Squamous cell carcinoma (SCC) accounted for 85.7% of cases, and 80.0% originated in the second branchial cleft. Integration of molecular imaging (18F\u2010FDG PET\/CT) with traditional diagnostic criteria significantly reduced occult primary tumor misdiagnosis. Disease\u2010free survival (DFS) reached 86.7% with surgery alone, yet an 11.4% recurrence rate underscored the need for adjuvant therapy. HPV positivity (5.7%) correlated significantly with prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While BC's status as an independent entity requires further molecular validation (e.g., whole\u2010exome sequencing), this study highlights the necessity for international multicenter collaborations to build large\u2010scale databases and explore chronic inflammation and immune microenvironment roles in carcinogenesis, advancing precision oncology paradigms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70209","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:13:56Z","timestamp":1772990036000},"page":"2087-2098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review of 33 Cases of Branchiogenic Carcinoma: Clinicopathological Features and Prognostic Outcomes"],"prefix":"10.1002","volume":"48","author":[{"given":"Jiayu","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology Jilin University  Changchun China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University  Changchun 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