{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:23:16Z","timestamp":1783164196526,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To report disease\u2010free survival (DFS) in p16\u2010positive non\u2010oropharyngeal head\u2010and\u2010neck squamous\u2010cell carcinoma (HNSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Curatively\u2010treated non\u2010oropharyngeal HNSCC (2009\u20132021) were reviewed. DFS was compared among p16\u2010positive, p16\u2010negative, and p16\u2010untested cases for the overall cohort and by disease site. Multivariable analysis estimated adjusted hazard ratio (aHR) for p16\u2010positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 3061 non\u2010oropharyngeal HNSCC, 91 p16+, 375 p16\u2212, 2595 untested; median follow\u2010up 4.7\u2009years. P16\u2010positive patients had superior 5\u2010year DFS versus p16\u2212\/untested (74% vs. 48%\/59%; aHR 0.40 [0.26\u20130.61],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). This advantage was evident in the larynx (86% vs. 52%\/63%; aHR 0.26 [0.09\u20130.71],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), hypopharynx (70% vs. 25%\/37%; aHR 0.55 [0.10\u20130.50],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and nasal cavity (82% vs. 38%\/66%; aHR 0.31 [0.11\u20130.88],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). No significant DFS differences were seen in paranasal sinus (40% vs. 64%\/41%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.39) or oral cavity (50% vs. 57%\/58%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.94).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>p16\u2010positivity confers a DFS benefit in larynx\/hypopharynx\/nasal cavity, but not in paranasal sinus or oral SCC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70230","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:12:07Z","timestamp":1773310327000},"page":"2156-2169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease Site\u2010Specific Outcomes in\n                    <scp>p<\/scp>\n                    16\u2010Positive Non\u2010Oropharyngeal Mucosal Head and Neck Cancer"],"prefix":"10.1002","volume":"48","author":[{"given":"Revadhi C.","family":"Chelvarajah","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lessandra Y. S.","family":"Chee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-716X","authenticated-orcid":false,"given":"Christopher M. K. L.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Sanz\u2010Garcia","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-5087","authenticated-orcid":false,"given":"Stephen M.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Bratman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. C. John","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hope","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hosni","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McPartlin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nauman","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8051-0787","authenticated-orcid":false,"given":"Chiaojung Jillian","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-5033","authenticated-orcid":false,"given":"John","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Spreafico","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-4388","authenticated-orcid":false,"given":"Shao Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"},{"name":"Department of Otolaryngology\u2010Head &amp; Neck Surgery, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, the Princess Margaret Cancer Centre University of Toronto  Toronto Canada"},{"name":"Department of Otolaryngology\u2010Head &amp; 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