{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:24:42Z","timestamp":1783164282054,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Oral epithelial dysplasia (\n                      <jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>\n                      ) often precedes oral squamous cell carcinoma (\n                      <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>\n                      ). The aim was to elucidate the risk and time of malignant transformation (\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      ) of\n                      <jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients diagnosed with\n                      <jats:styled-content style=\"fixed-case\">OED<\/jats:styled-content>\n                      between 2001 and 2011 in Helsinki and Uusimaa, Finland were included. Kaplan\u2013Meier and Cox proportional hazard analysis factors associated with the\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dysplasias of 225 patients (mean age 60.0\u2009years, 51.6% females) were diagnosed as mild (85.8%), moderate (11.6%), or severe (2.7%).\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      occurred in 14.7% (51.5% females, 48.5% males) at a median time of 5.5\u2009years (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      1.7\u201312.5\u2009years).\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      occurred in 33.3% of severe (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), 34.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926) of moderate, and 11.4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009193) of mild dysplasia. Dysplasia severity was associated with an increased risk for\n                      <jats:styled-content style=\"fixed-case\">MT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MT of OED was 14.7%. The severity of OED is a predictor for MT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70241","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T01:57:24Z","timestamp":1774576644000},"page":"2231-2237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Transformation of Oral Epithelial Dysplasia in Southern Finland"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0142-170X","authenticated-orcid":false,"given":"Katariina","family":"Leino","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna K.","family":"Laine","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Kinnula","sequence":"additional","affiliation":[{"name":"Biostatistics Center Helsinki University Hospital, University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Rautava","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki Finland"},{"name":"Department of Pathology, Helsinki University Hospital HUSLAB Diagnostics  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.06.002"},{"key":"e_1_2_11_3_1","unstructured":"Cancer A.o.t.N.C.R.I.A.f.R.o \u201cNORDCAN: Cancer Statistics for the Nordic Countries \u201d April 22 2024 https:\/\/nordcan.iarc.fr\/."},{"key":"e_1_2_11_4_1","unstructured":"Working Group Appointed by the Finnish Medical Society Duodecim t.F.D.S.A \u201cOral Cancer \u2010Current Care Guideline \u201d October 1 2019 https:\/\/www.kaypahoito.fi."},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519894963"},{"key":"e_1_2_11_6_1","unstructured":"Registry F.C \u201cFinnish Cancer Registry \u201d August 3 2025 https:\/\/cancerregistry.fi\/."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00106-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2023.04.017"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.61073"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14846"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13993"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.09.017"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-12441-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03938.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00782.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494820919572"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-13"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/854636"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21131"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2022.100664"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15400"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26006"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.15140"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00491.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12259"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90468-9"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-260"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2007.00579.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.12.011"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdip.2005.10.008"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)80007-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01054.x"},{"key":"e_1_2_11_35_1","volume-title":"Oral and Maxillofacial Pathology","author":"Neville B.","year":"2002"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80226-4"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:14:37Z","timestamp":1783163677000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/hed.70241"],"URL":"https:\/\/doi.org\/10.1002\/hed.70241","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"2026-01-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}