{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:23:46Z","timestamp":1783164226372,"version":"3.54.6"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16849"],"award-info":[{"award-number":["21K16849"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surveillance after transoral videolaryngoscopic surgery (TOVS) for early\u2010stage hypopharyngeal squamous cell carcinoma (HPSCC) remains unvalidated, particularly regarding posttreatment local recurrence and second primary head and neck squamous cell carcinoma (HNSCC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 84 patients with early\u2010stage HPSCC treated with TOVS at a single high\u2010volume center. Post\u2010TOVS \u201cHNSCC events\u201d were defined as local recurrence or second primary HNSCC diagnosed after TOVS. Event\u2010free survival (EFS) was defined as time to first post\u2010TOVS HNSCC event or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median follow\u2010up was 49.3\u2009months. Two\u2010year EFS and overall survival (OS) were 49.0% and 93.8%, and 2\u2010year cause\u2010specific survival was 100%. Prior HNSCC before the index HPSCC independently predicted worse EFS (HR 4.3, 95% CI 2.3\u20138.0;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001): 2\u2010year EFS was 73.8% without versus 23.0% with prior HNSCC, while OS and cause\u2010specific survival were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prior HNSCC is the dominant predictor of post\u2010TOVS EFS, supporting risk\u2010adapted surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70242","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:04:43Z","timestamp":1774033483000},"page":"2206-2216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["History of Head and Neck Cancer as a Predictor of Recurrence and Second Primary Tumors After Transoral Videolaryngoscopic Surgery in Patients With Hypopharyngeal Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"48","author":[{"given":"Mitsuhiko","family":"Katoh","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0922-9245","authenticated-orcid":false,"given":"Kohtaro","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takane","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azusa","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-9961","authenticated-orcid":false,"given":"Hideaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Esophageal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Esophageal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-095X","authenticated-orcid":false,"given":"Seiichi","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery National Cancer Center Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Japan Society for Head and Neck Cancer Cancer Registry Committee \u201cReport of Head and Neck Cancer Registry of Japan Clinical Statistics of Registered Patients 2020 \u201d2023 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