{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:54:53Z","timestamp":1790139293806,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003761","name":"Universitair Medisch Centrum Utrecht","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Growing interest in new radiotherapy strategies for early\u2010stage glottic cancer highlights the importance of reviewing current treatment outcomes. This nationwide study presents the incidence, survival, recurrences, and laryngectomies for these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients diagnosed with cT1\u20102N0M0 glottic squamous cell carcinoma (SCC) between 2015 and 2021 in the Netherlands were included. Patients diagnosed between 2015 and 2019 were analyzed for survival, recurrences, and laryngectomies after radiotherapy treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2214 patients were diagnosed with early\u2010stage glottic SCC. A total of 826 patients were treated with radiotherapy between 2015 and 2019. The 5\u2010year overall survival, relative survival, and recurrence\u2010free survival after radiotherapy were 75%, 88%, and 86%, respectively. Of the 826 patients, 47 (6%) underwent laryngectomy. Only four (0.5%) patients had a laryngectomy due to severe radiation toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This nationwide study demonstrates that radiotherapy for early\u2010stage glottic SCC results in excellent oncological outcomes. Radiation\u2010induced laryngectomies for this treatment are extremely rare.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70245","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:24:33Z","timestamp":1774488273000},"page":"2217-2223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early\u2010Stage Glottic Squamous Cell Carcinoma: A Nationwide Analysis on Incidence, Survival, Recurrences, and Laryngectomies After Radiotherapy in the Netherlands (2015\u20132021)"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5130-3760","authenticated-orcid":false,"given":"Sabine M. L.","family":"Linden","sequence":"first","affiliation":[{"name":"Department of Radiotherapy University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5984-4716","authenticated-orcid":false,"given":"Boukje A. C.","family":"van Dijk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University Medical Center Groningen  Groningen the Netherlands"},{"name":"Department of Research and Development Netherlands Comprehensive Cancer Organisation (IKNL)  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-3459","authenticated-orcid":false,"given":"Marielle E. P.","family":"Philippens","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-3667","authenticated-orcid":false,"given":"Gerben E.","family":"Breimer","sequence":"additional","affiliation":[{"name":"Department of Pathology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-5814","authenticated-orcid":false,"given":"Remco","family":"de Bree","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Rijken","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgical Oncology University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-3038","authenticated-orcid":false,"given":"Mischa","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.05.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282b6fd40"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021944123914"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21855"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.01.010"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.09.012"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"19","article-title":"Pathology Databanking and Biobanking in The Netherlands, a Central Role for PALGA, the Nationwide Histopathology and Cytopathology Data Network and Archive","volume":"29","author":"Casparie M.","year":"2007","journal-title":"Cellular Oncology"},{"key":"e_1_2_11_9_1","volume-title":"Revision of the European Standard Population\u2014Report of Eurostat's Task Force\u20142013 Edition","author":"European Commission","year":"2013"},{"key":"e_1_2_11_10_1","unstructured":"Surveillance Research Program National Cancer Institute Joinpoint Regression Software Version 5.2.0\u2014June 4 2024 2025 https:\/\/surveillance.cancer.gov\/joinpoint."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1501500112"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.07.002"},{"key":"e_1_2_11_13_1","unstructured":"Maatregelen overheid om roken te ontmoedigen https:\/\/www.rijksoverheid.nl\/onderwerpen\/roken\/roken\u2010ontmoedigen."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28388"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-5288"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2016.02.006"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28225"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-07904-2"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-193"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-013-2608-8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.08.066"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00932"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.09.063"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28139"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.03.011"}],"container-title":["Head &amp; 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