{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:50:12Z","timestamp":1791625812863,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Squamous cell carcinoma (SCC) of the dorsal tongue accounts for only 2%\u20135% of tongue cancers; midline dorsal tongue cancers account for less than 1% of these tumors. Basaloid SCC (BSCC) is usually associated with more aggressive features than conventional SCC. There are fewer than 30 reported cases of lingual BSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 76\u2010year\u2010old woman presented with irregular, exophytic, rugated, and furrowed changes of the midline dorsal tongue, which was initially misdiagnosed as mucoepidermoid carcinoma on an outside institution biopsy. Other than mild linear enhancement of the oropharyngeal tongue, MRI was unremarkable. A midline partial glossectomy with primary closure was performed with the aid of intraoperative frozen section analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Final pathology was rediagnosed as pT2 invasive BSCC, with depth of invasion of 2.43\u2009mm, worst pattern of invasion of WPOI\u20103, and negative final margins. The decision was made to proceed with surveillance without any adjuvant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first reported case of BSCC of the midline dorsal tongue. This case report highlights the diagnostic challenges of BSCC and underscores the importance of comprehensive evaluation of all histological features using immunohistochemistry studies, as BSCC can mimic other pathologic entities but may confer a different prognosis. Early and definitive diagnosis of this disease has implications for management decisions and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70250","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:12:05Z","timestamp":1775009525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basaloid Squamous Cell Carcinoma of the Midline Dorsal Tongue: Case Report and Review of the Literature"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7907-4883","authenticated-orcid":false,"given":"Jacob E.","family":"Kapustin","sequence":"first","affiliation":[{"name":"THANC (Thyroid, Head and Neck Cancer) Foundation  New York New York USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0524-0240","authenticated-orcid":false,"given":"Sabrina R.","family":"Comess","sequence":"additional","affiliation":[{"name":"THANC (Thyroid, Head and Neck Cancer) Foundation  New York New York USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Nurimba","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ike","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai, Mount Sinai West  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azita","family":"Khorsandi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Molecular and Interventional Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Brandwein\u2010Weber","sequence":"additional","affiliation":[{"name":"Department of Pathology Icahn School of Medicine at Mount Sinai, Mount Sinai West  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Urken","sequence":"additional","affiliation":[{"name":"THANC (Thyroid, Head and Neck Cancer) Foundation  New York New York USA"},{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-023-00249-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.10.023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15020451"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/01945998221098011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2017.68628"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-023-04149-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(200003)22:2<190::AID-HED12>3.0.CO;2-O"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33157.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.11.022"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002423"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027665"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.113161"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102645"},{"issue":"4","key":"e_1_2_8_15_1","article-title":"Basaloid Squamous Cell Carcinoma of the Dorsum of the Tongue Following Chronic Hypertrophic Candidiasis: A Case Report and Literature Review","volume":"17","author":"Kyoda S.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80422-1"},{"key":"e_1_2_8_17_1","unstructured":"Organisation mondiale de la sant\u00e9 \u201cCentre international de recherche sur le cancer editors. Head and Neck Tumours. 5th ed. Lyon: International agency for research on cancer \u201d2025 (World health organization classification of tumours)."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000669"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xocr.2020.100159"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.25259\/JSSTD_21_2022"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2023.07.004"},{"issue":"5","key":"e_1_2_8_22_1","first-page":"1605","article-title":"Basaloid Lesions of Oral Squamous Epithelial Cells and Their Association With HPV Infection and P16 Expression","volume":"30","author":"Friedrich R. E.","year":"2010","journal-title":"Anticancer Research"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3353\/omp.15.117"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6036567"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb00199.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0045-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200009000-00013"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.190964"},{"issue":"3","key":"e_1_2_8_29_1","first-page":"ZD16","article-title":"Basaloid Squamous Cell Carcinoma of the Tongue: A Report With Emphasis on Immunohistochemistry","volume":"11","author":"Kumari K.","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12986"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10006-020-00828-9"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.jomfp_382_21"},{"issue":"1","key":"e_1_2_8_33_1","first-page":"62","article-title":"Clinicopathological Study in 28 Cases of Oral Basaloid Squamous Cell Carcinomas","volume":"54","author":"Zhou C. X.","year":"2022","journal-title":"Beijing Da Xue Xue Bao. Yi Xue Ban"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.134826.3"},{"issue":"2","key":"e_1_2_8_35_1","first-page":"244","article-title":"Course and Prognosis of Basaloid Squamous Cell Carcinoma of the Head and Neck: A Case\u2010Control Study of 62 Patients","volume":"44","author":"Soriano E.","year":"2008","journal-title":"European Journal of Cancer 1990"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.1.83"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.20274"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00098.2022"},{"issue":"6","key":"e_1_2_8_39_1","article-title":"Prognostic Implications Across Histological Subtypes of Head and Neck Squamous Cell Carcinoma: An Update","volume":"126","author":"Gon\u00e7alves M. W. A.","year":"2025","journal-title":"Journal of Maxillofacial and Oral Surgery"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800670210"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0007-117X(78)90021-5"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:18:36Z","timestamp":1791623916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/hed.70250"],"URL":"https:\/\/doi.org\/10.1002\/hed.70250","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}