{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:11:07Z","timestamp":1790345467957,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Submental artery island flap is a pedicled regional flap which is used as one of the quicker reconstructive options for oral cavity defects. However, concerns about its oncological safety have been raised due to the proximity of the submental lymph nodes, which may harbor metastatic deposits. This study aimed to systematically evaluate the oncological safety of the SAIF oral cavity reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was conducted according to the PICO model. Studies were included if they assessed the oncological safety of the SAIF in oral cavity reconstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The use of SAIF for oral cavity reconstruction appears to provide reasonable oncological safety in terms of locoregional recurrence. The overall pooled recurrence rate across the studies was 16% (95% CI: 14%\u201318%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review demonstrates that the submental artery island flap is an oncologically safe and reliable reconstructive option for oral cavity defects following OSCC resection in carefully selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70252","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:50:46Z","timestamp":1775641846000},"page":"2470-2482","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oncological Safety of the Submental Artery Island Flap for Oral Reconstruction: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-3679","authenticated-orcid":false,"given":"Shafaq","family":"Taseen","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4416-4379","authenticated-orcid":false,"given":"Muhammad Fazal Hussain","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Centre for Patient Safety Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1057-7036","authenticated-orcid":false,"given":"Munib","family":"Abbas","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-0669","authenticated-orcid":false,"given":"Shayan K.","family":"Ghaloo","sequence":"additional","affiliation":[{"name":"Department of ENT, Head &amp; Neck Surgery University Hospital Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3760-484X","authenticated-orcid":false,"given":"Muhammad","family":"Wasif","sequence":"additional","affiliation":[{"name":"Department of ENT, Head &amp; Neck Surgery University Hospital Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3266-4015","authenticated-orcid":false,"given":"Haissan","family":"Iftikhar","sequence":"additional","affiliation":[{"name":"Department of ENT, Head &amp; Neck Surgery University Hospital Northamptonshire NHS Group  Northampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6349-7024","authenticated-orcid":false,"given":"Hamdan A.","family":"Pasha","sequence":"additional","affiliation":[{"name":"ENT &amp; Head and Neck Surgery, Department of Surgery Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-862X","authenticated-orcid":false,"given":"Rahim","family":"Dhanani","sequence":"additional","affiliation":[{"name":"ENT &amp; Head and Neck Surgery, Department of Surgery Aga Khan University  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1991.01870200051007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199392050-00013"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26121"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106395"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.37029\/jcas.v10i2.573"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2025.102309"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.02.013"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000001281"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000267343.10982.dc"},{"issue":"2","key":"e_1_2_10_12_1","first-page":"153","article-title":"Submental Artery Flap With Sentinel Lymph Node Biopsy in the Reconstruction of Oral Cancer","volume":"32","author":"Husso A.","year":"2016","journal-title":"Journal of Reconstructive Microsurgery"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.03.011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-03955-x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2017.11.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2019.104507"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/ams.ams_225_18"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814520687"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26338"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2020.08.120"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2021.05.010"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.05.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2024.09.005"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-022-00343-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-022-03345-1"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-05103-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-24293-4"},{"issue":"1","key":"e_1_2_10_28_1","first-page":"315","article-title":"Submental Island Flap for Reconstruction of Oral Cancer Post Resection Defects: Surgical Outcomes and Oncological Safety","volume":"90","author":"Zaid A. M.","year":"2022","journal-title":"Medical Journal of Cairo University"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0532-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-023-04286-z"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adoms.2021.100082"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2018.06.006"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2021.103142"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819875416"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32832cee83"},{"issue":"3","key":"e_1_2_10_36_1","first-page":"244","article-title":"Narrative Review: Submental Artery Island Pedicled Flap, Indications, Tips, and Pitfalls","volume":"17","author":"Mosquera C.","year":"2024","journal-title":"Craniomaxillofacial Trauma & Reconstruction"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.21608\/mjcu.2022.234981"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-016-0124-8"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.28043"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:33:23Z","timestamp":1786113203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/hed.70252"],"URL":"https:\/\/doi.org\/10.1002\/hed.70252","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2026-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}