{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:51:51Z","timestamp":1791982311637,"version":"4.4.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["K01 DE030916"],"award-info":[{"award-number":["K01 DE030916"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE032216"],"award-info":[{"award-number":["R01 DE032216"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study examined the relationship between postoperative opioid duration and new\u2010onset depression following head and neck cancer (HNC) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of opioid\u2010na\u00efve patients undergoing HNC surgery from 2007 to 2020, using national Veterans Health Administration claims data. Postoperative opioid duration was categorized as 1\u201330\u2009days, 31\u201390\u2009days, or &gt;\u200990\u2009days (long\u2010term opioid therapy [LTOT]). The primary outcome was new\u2010onset depression within 24\u2009months. Competing risk survival models with entropy balancing evaluated associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 9148 patients, 24.3% received LTOT. Rates of new\u2010onset depression per 1000 person\u2010years were 46.8 (1\u201330\u2009days), 70.2 (31\u201390\u2009days), and 88.4 (LTOT). LTOT was associated with a 20% increased risk of depression compared with 1\u201330\u2009days of use. LTOT was associated with higher rates of comorbidities, non\u2010cancer pain, anxiety, substance use, and preoperative benzodiazepine use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LTOT was independently associated with higher risk of depression after HNC surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70254","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:25:36Z","timestamp":1776335136000},"page":"2660-2668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cumulative Incidence and Risk of Depression After Opioid Use in Head and Neck Cancer Patients"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-9753","authenticated-orcid":false,"given":"Nosayaba","family":"Osazuwa\u2010Peters","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery &amp; Communication Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Department of Population Health Sciences Duke University School of Medicine  Durham North Carolina USA"},{"name":"Duke Cancer Institute  Durham North Carolina USA"},{"name":"Center for the Study of Suicide Prevention and Intervention Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine  Durham North Carolina 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Psychiatry and Behavioral Sciences University of Washington School of Medicine  Seattle Washington USA"},{"name":"Department of Psychosocial Oncology Fred Hutchinson Cancer Center  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey F.","family":"Scherrer","sequence":"additional","affiliation":[{"name":"Advanced HEAlth Data (AHEAD) Research Institute Saint Louis University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Psychiatry and Behavioral Neuroscience Saint Louis University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Family and Community Medicine Saint Louis University School of Medicine  St. Louis Missouri USA"},{"name":"Department of Health and Clinical Outcomes Research Saint Louis University School of Medicine  St. Louis Missouri 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