{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:51:47Z","timestamp":1791982307454,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nasopharyngeal non\u2010intestinal\u2010type adenocarcinoma (non\u2010ITAC) is a rare malignancy of the nasopharynx. Here, we report a case of nasopharyngeal non\u2010ITAC that showed a favorable response to intensity\u2010modulated proton therapy (IMPT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 56\u2010year\u2010old man presented with otitis media with effusion. Nasopharyngoscopy revealed a mass in the left nasopharyngeal wall, and biopsy confirmed low\u2010grade non\u2010ITAC. Imaging examinations showed no evidence of invasion or metastasis, and the tumor was staged as cT1N0M0. Given the risk of an insufficient deep margin with surgery, the patient underwent IMPT (64 GyRBE in 16 fractions).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient developed acute treatment\u2010related mucositis but successfully completed the planned treatment. Imaging confirmed complete remission of the tumor, and he remains disease\u2010free after 2\u2009years of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case demonstrates successful management of nasopharyngeal non\u2010ITAC treated with IMPT, suggesting it to be a promising option for inoperable tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70255","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:11:52Z","timestamp":1774923112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Favorable Response to Intensity\u2010Modulated Proton Therapy for Nasopharyngeal Non\u2010Intestinal\u2010Type Adenocarcinoma: A Case Report"],"prefix":"10.1002","volume":"48","author":[{"given":"Naoya","family":"Sanda","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Toyota Kosei Hospital  Toyota Japan"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9391-5634","authenticated-orcid":false,"given":"Michi","family":"Sawabe","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Toyota Kosei Hospital  Toyota Japan"},{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoriko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pathology Toyota Kosei Hospital  Toyota Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-9800","authenticated-orcid":false,"given":"Hiromitsu","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Nagoya Proton Therapy Center, Nagoya City University West Medical Center  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery Nagoya City University Graduate School of Medicine  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(19)30956\u20100"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743\u20107563.2011.01499.x"},{"key":"e_1_2_8_4_1","volume-title":"Head and Neck Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.24.3299"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21770"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23900"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.08.201"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13718"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.01.017"},{"key":"e_1_2_8_11_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar A. K. C. J.","year":"2017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457934"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2021.151709"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2018.11.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.14338\/ijpt\u201020\u201000082.1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.14338\/ijpt\u2010d\u201020\u201000043.1"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70255","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:21:07Z","timestamp":1791980467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/hed.70255"],"URL":"https:\/\/doi.org\/10.1002\/hed.70255","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"2025-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}