{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T09:50:09Z","timestamp":1791625809747,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the feasibility of a tapered optical fiber sensor (TOFS) platform for sensitive detection of a cancer\u2010associated biomarker and a viral target in biologically relevant media.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>Experimental proof\u2010of\u2010concept study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TOFS devices were functionalized with antibody\u2013antigen complexes directed against interleukin\u20108 (IL\u20108) and human coronavirus OC43 (HCoV\u2010OC43). IL\u20108 detection was evaluated in phosphate\u2010buffered saline, and HCoV\u2010OC43 detection was evaluated in saliva. Sensor performance was assessed by measuring optical phase changes generated by target binding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TOFS detected IL\u20108 at low concentrations in phosphate\u2010buffered saline, supporting its utility for sensitive protein detection. The platform also detected HCoV\u2010OC43 in saliva, demonstrating feasibility in a complex biologic matrix. Together, these results show that TOFS can be adapted to distinct targets in different media while maintaining high analytical sensitivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the feasibility of TOFS as a rapid, portable, and potentially low\u2010cost sensing platform for biomarker and pathogen detection. Further validation in clinically derived specimens is warranted to define its role in point\u2010of\u2010care diagnostic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70267","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:16:22Z","timestamp":1779344182000},"page":"3089-3096","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of Label\u2010Free Detection Using Tapered Optical Fiber System for Head and Neck Cancer and Infectious Biomolecules"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9703-6170","authenticated-orcid":false,"given":"Casey","family":"Collet","sequence":"first","affiliation":[{"name":"Keck School of Medicine, Caruso Department of Otolaryngology \u2010 Head and Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Electro\u2010Optics and Photonics University of Dayton  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-367X","authenticated-orcid":false,"given":"De\u2010Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, Caruso Department of Otolaryngology \u2010 Head and Neck Surgery University of Southern California  Los Angeles California USA"},{"name":"Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, and Norris Comprehensive Cancer Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheyhun","family":"Nam","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, Caruso Department of Otolaryngology \u2010 Head and Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaminda","family":"Ranathunga","sequence":"additional","affiliation":[{"name":"Department of Electro\u2010Optics and Photonics University of Dayton  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Electro\u2010Optics and Photonics University of Dayton  Dayton Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-8904","authenticated-orcid":false,"given":"Uttam","family":"Sinha","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, Caruso Department of Otolaryngology \u2010 Head and Neck Surgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","first-page":"96","volume-title":"Proceedings of SPIE","author":"Deng C.","year":"2020"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios11100396"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2015.03.006"},{"key":"e_1_2_10_6_1","volume-title":"WHO Classification of Head and Neck Tumours","author":"El\u2010Naggar A. 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