{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:23:49Z","timestamp":1786123429224,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp;amp; Neck"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Head and neck squamous cell carcinoma (HNSCC) is the most common head and neck cancer in India, where intensity\u2010modulated radiation therapy (IMRT) is the standard treatment. Despite therapeutic advances, variability in radiation response and toxicities persists. Genetic factors, including the TNFRSF1A (\u2212135\u2009T&gt;C, rs767455) polymorphism, may influence susceptibility to oral mucositis, dermatitis, and treatment response, but remain insufficiently studied in Indian populations. Functional validation through serum TNF\u2010\u03b1 profiling and predictive modeling is also lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 50 patients with locally advanced HNSCC were treated with IMRT (70\u2009Gy\/35 fractions) and weekly cisplatin (40\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ). Pre\u2010treatment blood samples were analyzed for TNFRSF1A genotyping (PCR\u2013RFLP) and serum TNF\u2010\u03b1 levels (ELISA). Oral mucositis and dermatitis were graded weekly using CTCAE v4.0, and treatment response was evaluated 90\u2009days post\u2010therapy by RECIST 1.1. Statistical analyses included Chi\u2010square\/Fisher's exact tests, odds ratios, Kruskal\u2013Wallis ANOVA, and multivariate regression. A Random Forest model was applied for predictive evaluation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genotype distribution was TT (52.0%), TC (38.0%), and CC (10.0%). Carriers of the C allele (TC\/CC) had a significantly higher risk of severe mucositis (OR\u2009=\u20094.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010), while no association was observed with dermatitis. The TT genotype correlated with complete response (OR\u2009=\u20097.00,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and higher median serum TNF\u2010\u03b1 levels (13.28\u2009pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.041). Multivariate analysis confirmed TNFRSF1A genotype as an independent predictor of mucositis and response, while age was protective against dermatitis. The Random Forest model achieved 60% accuracy in predicting treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TNFRSF1A (\u2212135\u2009T&gt;C) polymorphism influences both toxicity and response in HNSCC, with the C allele predisposing to mucositis and the TT genotype predicting favorable outcomes. It represents a potential biomarker for personalized radiotherapy, meriting validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70277","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:49:36Z","timestamp":1775641776000},"page":"2505-2513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>TNFRSF1A<\/scp>\n                    (\u2212135\u2009T&gt;C, rs767455) Polymorphism as a Predictor of Radiation Induced Oral Mucositis and Treatment Response in Locally Advanced Head and Neck Cancer Patients"],"prefix":"10.1002","volume":"48","author":[{"given":"M. P.","family":"Sarath Krishnan","sequence":"first","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-9956","authenticated-orcid":false,"given":"Bela","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweety","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of General Surgery &amp; In\u2010Charge of Surgical Oncology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anissa Atif","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of Biochemistry All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/crst.crst_118_23"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2014.01.001"},{"issue":"3","key":"e_1_2_12_4_1","article-title":"A Prospective Cohort Study Analyzing Radiation\u2010Induced Xerostomia and Quality of Life of Head and Neck Cancer Patients Treated With Intensity\u2010Modulated Radiotherapy and 3D Conformal Radiotherapy Techniques at a Tertiary Cancer Center in Eastern India","volume":"15","author":"Sahoo S. 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