{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:49:18Z","timestamp":1791982158765,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Head &amp; Neck"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While accepted as a viable initial management option for properly selected small (&lt;\u20091.5\u2009cm) papillary thyroid cancer (PTC), the natural history and clinical outcomes of active surveillance in larger tumors are not well described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective chart review of patients with PTC &gt;\u20091.5\u2009cm opting for active surveillance as part of routine clinical care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 45 patients with PTC &gt;\u20091.5\u2009cm (range 1.6\u20132.9\u2009cm) followed with active surveillance for a median of 4.2\u2009years: 6 patients (13%, 6\/45) demonstrated an increase in tumor volume, 5 patients (11%, 5\/45) demonstrated newly identified cervical lymph node metastasis. Only 9 patients (20%, 9\/45) transitioned to surgical intervention with no evidence of disease, a median of 3.1\u2009years after surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that active surveillance is a viable initial management option in properly selected patients with PTC greater than 1.5\u2009cm in maximal diameter.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hed.70279","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:58:12Z","timestamp":1776405492000},"page":"2669-2676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Active Surveillance in Papillary Thyroid Cancer With Primary Tumors Greater Than 1.5\u2009cm"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8702-8249","authenticated-orcid":false,"given":"Lina Pedraza","family":"Sanchez","sequence":"first","affiliation":[{"name":"Endocrinology Service, Head and Neck Department Moffit Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Hintze","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"Newman","sequence":"additional","affiliation":[{"name":"Endocrinology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7478-9436","authenticated-orcid":false,"given":"Ashok","family":"Shaha","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc G.","family":"Morris","sequence":"additional","affiliation":[{"name":"Head and Neck Surgery Service, Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Tuttle","sequence":"additional","affiliation":[{"name":"Endocrinology Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.26348"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2024.1937"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010025\u201001168\u2010y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/10507256251363120"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0040"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2021.0539"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201025\u20100287"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2023.1794"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz113"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2022.0325"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.3875"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/wjs.12417"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0462"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae082"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2024.1699"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1442"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2018.1449641"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0319"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010024\u201009141\u20107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.03.028"}],"container-title":["Head &amp; Neck"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hed.70279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hed.70279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:20:44Z","timestamp":1791980444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hed.70279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/hed.70279"],"URL":"https:\/\/doi.org\/10.1002\/hed.70279","archive":["Portico"],"relation":{},"ISSN":["1043-3074","1097-0347"],"issn-type":[{"value":"1043-3074","type":"print"},{"value":"1097-0347","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"2026-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}